Evidence map›Paper›PMID 41025901›Full record

ArticleEpigenomics2025

Dissecting epigenetic age acceleration in amyotrophic lateral sclerosis.

Polina Merbaum, Ramona Zwamborn, Paul Hop, Project MinE Als Sequencing Consortium, Wouter van Rheenen, Jan Veldink

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PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Polina MerbaumDepartment of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0001-6015-1554
Ramona ZwambornDepartment of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0003-3952-5042
Paul HopDepartment of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-9007-7436
Project MinE Als Sequencing ConsortiumProject MinE Sequencing Consortium, Utrecht, The Netherlands.
Wouter van RheenenDepartment of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-5860-1533
Jan VeldinkDepartment of Neurology, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0001-5572-9657

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimWe compared signatures of epigenetic aging in amyotrophic lateral sclerosis (ALS) patients and healthy controls to investigate the role of potential confounders and genetic subgroups.

methodsWe used whole-blood methylome profiles for 5,146 ALS patients and 2,156 controls available for Project MinE. We predicted biological age with three generations of epigenetic clocks and estimated age acceleration by regressing our model on control individuals to evaluate case/control differences. To investigate the contribution of

resultsWe found that white blood cell type proportions confound the previously observed increase in the pace of biological aging in ALS. When correcting for cell counts, there is no evidence for accelerated epigenetic aging compared to controls, except for ALS patients with the

conclusionOur study revealed no significant difference in the pace of biological agingbetween ALS patients and controls, except for ALS patients carrying the

Indexed as

AgingAmyotrophic Lateral SclerosisEpigenesis, GeneticAdultAgedC9orf72 ProteinCase-Control StudiesDNA MethylationFemaleHumansMaleMiddle AgedC9orf72 ProteinC9orf72 protein, humanage accelerationALSC9orf72 repeat expansionepigenetic clockEpigeneticsepigenetics and diseaseneurodegeneration

Identifiers

PMID41025901
PMCPMC12562728

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.