Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
5 authors.
Cristina C VacaDepartment of Medicine, Division of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Hannah HudsonDepartment of Medicine, Division of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Isabelle ClercDepartment of Medicine, Division of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Chisu SongDepartment of Medicine, Division of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Richard T D'AquilaDepartment of Medicine, Division of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0002-9653-5987
Funding
Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Virology and Immunology Technology CoreP30AI117943 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Sahera Dirajlal-Fargo · 2015 to 2026
$38.4M
The RADAR cohort study of multilevel Influences on HIV and substance useU01DA036939 · NIDA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Brian Mustanski, Michael E Newcomb · 2014 to 2026
$29.5M
Pathogenesis of Rebound SIV/HIV Viremia after Antiretrovral TherapyP01AI131346 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2017 to 2021
$8.0M
TRAINING PROGRAM IN IMMUNOLOGY &MOLECULAR PATHOGENESIST32AI007476 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Edward Benjamin Thorp · 1996 to 2026
$6.6M
National Institute of Allergy and Infectious Diseases P01 AI 131346NCATS NIH HHS UL1 TR 001422NCATS NIH HHS UL1 TR001422NIAID NIH HHS P01 AI131346NIAID NIH HHS P30 AI117943NIAID NIH HHS T32 AI007476NIDA NIH HHS U01 DA 036939NIDA NIH HHS U01 DA036939
6 · The paper itself
Abstract
A spreading infection can quickly restart from the persistent reservoir of cells harboring HIV proviruses if antiretroviral therapy (ART) is stopped. HIV transcription can also be increased by latency-reversing agents (LRAs) during ART. Neddylation is a post-translational modification that activates Cullin-RING ligases (CRLs), which ubiquitinate several proteins that regulate HIV transcription and infectivity, marking these regulators for proteasomal degradation. We studied how inhibiting neddylation affects HIV gene expression
Indexed as
HIV-1HIV InfectionsProvirusesTranscription, GeneticAzepinesCD4-Positive T-LymphocytesCyclopentanesHumansIonomycinProtein Processing, Post-TranslationalPyrimidinesTriazolesUbiquitinationVirus ActivationVirus LatencyAzepinesCyclopentanesIonomycin(+)-JQ1 compoundpevonedistatPyrimidinesTriazolesAPOBEC3GCullin-RING ligases (CRLs)HIVHIV cure researchHIV latencyHIV latency-reversing agents (LRAs)HIV reactivationinhibitor of kB alpha (IkBα)JQ1latency-reversing agentsneddylationNF-kBPMA and ionomycinshock and killstrategies for ART-free remission of HIV infectionTNFα
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
HIV proviral transcription and infectivity are enhanced by neddylation. · full record | OpenQuestion