Evidence map›Paper›PMID 41025831›Full record

ArticleMicrobiology spectrum2025

Restoring colistin sensitivity in colistin-resistant gram-negative bacteria: combinatorial use of α-terpineol and colistin.

Yuhan Yang, Panjie Hu, Yanchun Gong, Zeyong Zhong, Yichi Zhang, Fan Ye, Tieli Zhou, Jianming Cao, Zhongyong Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuhan YangSchool of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, China.
Panjie HuDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yanchun GongDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Zeyong ZhongSchool of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, China.
Yichi ZhangDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Fan YeDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Tieli ZhouDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.ORCID 0000-0002-2171-4710
Jianming CaoSchool of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, China.ORCID 0000-0002-9968-6721
Zhongyong WangDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.ORCID 0000-0002-3606-794X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multidrug-resistant gram-negative bacteria (GNB) have posed a serious public health hazard worldwide. Colistin (COL), the ultimate therapeutic option for treating GNB infections, has had escalating resistance rates concomitant with increased utilization. In this study, we attempted to increase the sensitivity to COL using a plant extract, α-terpineol (α-TP). Checkerboard and time-kill assays indicated that the combination of COL and α-TP exhibited pronounced synergistic antimicrobial effects against colistin-resistant (COL-R) GNB IMPORTANCE: Colistin (COL) has emerged as a last-line therapeutic agent for gram-negative bacteria (GNB) infections. However, widespread antibiotic use has led to an alarming increase in the number of colistin-resistant (COL-R) strains. In this study, we demonstrate that combining COL with a plant-derived extract could effectively restore the susceptibility of COL-R GNB. A possible treatment plan for COL-R GNB is presented.

Indexed as

Anti-Bacterial AgentsColistinCyclohexane MonoterpenesGram-Negative BacteriaBiofilmsDrug Resistance, BacterialDrug Resistance, Multiple, BacterialDrug SynergismGram-Negative Bacterial InfectionsHumansMicrobial Sensitivity TestsReactive Oxygen Speciesalpha-terpineolAnti-Bacterial AgentsColistinCyclohexane MonoterpenesReactive Oxygen Speciesbiofilmcolistin resistancegram-negative bacteriasynergistic antimicrobial effectsα-terpineol

Identifiers

PMID41025831
PMCPMC12584673

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.