Evidence map›Paper›PMID 41025791›Full record

ArticlemBio2025

Polycomb repressive complex 2 regulates sexual development in

Abigail M Deaven, Abigail J Ameri-Solanky, Zachary A Lewis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. HISTONE DEACETYLASE-1 is required for epigenome stability inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Abigail M DeavenDepartment of Microbiology, The University of Georgia, Athens, Georgia, USA.ORCID 0000-0001-9682-9064
Abigail J Ameri-SolankyDepartment of Microbiology, The University of Georgia, Athens, Georgia, USA.
Zachary A LewisDepartment of Microbiology, The University of Georgia, Athens, Georgia, USA.ORCID 0000-0002-1735-8266

Funding

T32 Predoctoral Training Grant in GeneticsT32GM142623 · NIGMS · UNIVERSITY OF GEORGIA · PI Kelly A Dyer, Mary Grace Goll · 2022 to 2026
$2.1M
Transcriptional repression by Polycomb Repressive Complex 2R01GM132644 · NIGMS · UNIVERSITY OF GEORGIA · PI LEWIS, ZACHARY · 2019 to 2022
$1.6M
Control and function of repressive chromatin domainsR35GM152134 · NIGMS · UNIVERSITY OF GEORGIA · PI Zachary Lewis · 2024 to 2026
$1.1M
NIGMS NIH HHS R01 GM132644NIGMS NIH HHS R35 GM152134NIGMS NIH HHS T32 GM142623NIH HHS R35AGM152134
6 · The paper itself

Abstract

In most branches of the fungal kingdom, sexual development marks a dramatic shift from simple multicellular hyphae to complex fruiting bodies composed of multiple tissues and cell types. It is essential to tightly regulate development to prevent unnecessary energy investment into building these structures. Polycomb repressive complex 2 (PRC2) is a highly conserved regulator of development in multicellular organisms. In plants, animals, and some fungi, PRC2 tri-methylates histone H3 lysine 27 in promoters and gene bodies to repress gene expression. In

Indexed as

Fungal ProteinsGene Expression Regulation, FungalNeurospora crassaPolycomb Repressive Complex 2Sexual DevelopmentHistonesFungal ProteinsHistonesPolycomb Repressive Complex 2chromatin modificationH3K27me3Neurospora crassaperitheciumPolycomb repressionsexual development

Identifiers

PMID41025791
PMCPMC12607757

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.