Evidence map›Paper›PMID 41025790›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2025

Pleomorphism in Wild-Type and Engineered PP7 Virus-Like Particles.

Parisa Keshavarz-Joud, Matthew C Jenkins, Tahiti Dutta, Liangjun Zhao, Carolina Hernandez, Daija Bobe, Mohammadreza Paraan, M G Finn, Mykhailo Kopylov

Abstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Characterization Standard forbioRxiv : the preprint server for biology · 2026
    Article
  3. Pleomorphism in Wild-Type and Engineered PP7 Virus-Like Particles.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Parisa Keshavarz-JoudSchool of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA, 30306, USA.
Matthew C JenkinsSchool of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA, 30306, USA.
Tahiti DuttaSchool of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA, 30306, USA.
Liangjun ZhaoSchool of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA, 30306, USA.
Carolina HernandezNew York Structural Biology Center, 89 Convent Ave, New York, NY, 10027, USA.
Daija BobeNew York Structural Biology Center, 89 Convent Ave, New York, NY, 10027, USA.
Mohammadreza ParaanNew York Structural Biology Center, 89 Convent Ave, New York, NY, 10027, USA.
M G FinnSchool of Chemistry and Biochemistry, School of Biological Sciences, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA, 30306, USA.ORCID 0000-0001-8247-3108
Mykhailo KopylovNew York Structural Biology Center, 89 Convent Ave, New York, NY, 10027, USA.

Funding

Molecular Interactions of HIV-1 with the Nuclear Pore ComplexR01AI148382 · NIAID · EMORY UNIVERSITY · PI MELIKIAN, GREGORY B, SARAFIANOS, STEFAN G · 2019 to 2022
$5.5M
Defense Threat Reduction Agency HDTRA1-18-1-0029NIAID NIH HHS R01 AI148382Simons Foundation SF349247
6 · The paper itself

Abstract

Virus-like particles (VLPs) find applications across many different fields, aided by their stability, capacity for large-scale production, and presumed structural homogeneity. These attributes are a result of their highly efficient self-assembly, which stems from the evolutionary pressures on the natural viruses from which they are derived. It is found that VLPs based on the Leviphage PP7 assemble in an unexpectedly wide range of morphologies. The relative abundance of these structures is sensitive to small changes in the coat protein sequence. These results raise the possibility that structural plasticity may be a general property of such self-assembling structures rather than an exception.

Indexed as

VirionCapsid ProteinsCapsid Proteinscryo electron microscopystructural diversitystructurevirus‐like particles

Identifiers

PMID41025790
PMCPMC12710124

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.