Evidence map›Paper›PMID 41025721›Full record

ArticleHistology and histopathology2026

PIP5K3 upregulation correlates with unfavorable prognosis in patients with nasopharyngeal carcinoma.

Szu-Chi Yao, Hung-Chang Wu, Ching-Chieh Yang, Yun-Tzu Lin, Chien-Feng Li, Shih-Lun Chang, Yu-Hsuan Kuo

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Article in Histology and histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Szu-Chi YaoDivision of Hematology and Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Tainan, Taiwan.
Hung-Chang WuDivision of Hematology and Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Tainan, Taiwan.
Ching-Chieh YangCollege of Pharmacy and Science, Chia Nan University, Tainan, Taiwan.
Yun-Tzu LinDivision of Hematology and Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Tainan, Taiwan.
Chien-Feng LiInstitute of Precision Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.
Shih-Lun ChangDepartment of Otorhinolaryngology, Chi-Mei Medical Center, Tainan, Taiwan. c3224710@ms16.hinet.net.
Yu-Hsuan KuoCollege of Pharmacy and Science, Chia Nan University, Tainan, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNasopharyngeal carcinoma (NPC) is prevalent in East and Southeast Asia, with metastasis and recurrence leading to poor prognosis. Identifying prognostic biomarkers is essential.

methodsWe analyzed differentially expressed genes involved in the phosphatidylinositol metabolic process (GO: 0046488) and tumorigenesis (GSE12452) in NPC. Associations between PIP5K3 expression and clinicopathological features were assessed using chi-square tests and Cox proportional hazards models.

resultsPIP5K3 was significantly upregulated in NPC tissues, correlating with advanced stage (

conclusionsPIP5K3 upregulation is associated with unfavorable clinical outcomes in NPC and may serve as a novel prognostic biomarker and potential therapeutic target.

Indexed as

Biomarkers, TumorNasopharyngeal CarcinomaNasopharyngeal NeoplasmsPhosphotransferases (Alcohol Group Acceptor)AdultAgedFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedPrognosisUp-Regulation1-phosphatidylinositol-4-phosphate 5-kinaseBiomarkers, TumorPhosphotransferases (Alcohol Group Acceptor)

Identifiers

PMID41025721

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.