Genomic Characterization of Pan-Drug Resistant Klebsiella pneumoniae KPNW Isolated From UTI Patient in Bangladesh.

Md Wahid Murad, G M Shah Poran, Kalpana Baidya, Nazmul Ahsan

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Article in MicrobiologyOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 citing paper in PubMed.

Molecular determinants of antimicrobial resistance inMicrobiology spectrum · 2026
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5 · Who and what money

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4 authors.

Md Wahid MuradDepartment of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka, Bangladesh.ORCID 0000-0003-0963-415X

G M Shah PoranDepartment of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka, Bangladesh.

Kalpana BaidyaDepartment of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka, Bangladesh.

Nazmul AhsanDepartment of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka, Bangladesh.ORCID 0009-0008-3818-8682

Funding

The study was funded by a research grant received from the Biotechnology Research Center, University of Dhaka (Ref. BRC/28; Session 2022-2023).

6 · The paper itself

Abstract

Klebsiella pneumoniae is a Gram-negative opportunistic bacterial pathogen and a common cause of urinary tract infections (UTIs). In Bangladesh, a rapid increase in antibiotic resistance in K. pneumoniae, with a concerning prevalence of pan-drug resistant (PDR) isolates, is severely limiting treatment options and posing a threat to public health. K. pneumoniae isolate KPNW was found in a clinical urine sample of a UTI patient from Dhaka, Bangladesh. In the disc diffusion test, KPNW showed resistance to 28 antibiotics across multiple classes, including carbapenems and colistin. Whole genome sequencing, assembly, and annotation yielded a 5.48 Mb genome encoding 5554 genes. Four plasmid replicons-lncFIB(K), lncFII(K), lncN2, and lncX3-were identified, all having known associations with antimicrobial resistance (AMR). KPNW belongs to multilocus sequence typing sequence type ST15 and capsular type KL112 and O1v2. We detected 42 AMR genes, including extended-spectrum β-lactamases, carbapenemase bla

Indexed as

Drug Resistance, Multiple, BacterialKlebsiella InfectionsKlebsiella pneumoniaeUrinary Tract InfectionsAnti-Bacterial AgentsBacterial ProteinsBangladeshbeta-LactamasesGenome, BacterialGenomicsHumansMicrobial Sensitivity TestsMultilocus Sequence TypingPlasmidsWhole Genome SequencingAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamasesantibiotic resistanceantimicrobial resistancegenome sequenceKlebsiella pneumoniaepan‐drug resistanceurinary tract infection

Identifiers

PMID41025610

DOI10.1002/mbo3.70064

PMCPMC12481437

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