ArticleJournal of the American Heart Association2025
Carotid Plaques Show More Unstable Characteristics Between 2010 and 2021 After a Prior Decade of Stabilization.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPreviously we reported a time-dependent change in atherosclerotic carotid plaque characteristics, with decreasing destabilizing characteristics between 2002 and 2011. This observation was considered confirmative with a parallel improved adherence to medication and decrease in overall cardiovascular death in Western Europe. In the present study, we investigated whether these time-dependent changes in plaque characteristics still occurred over the past decade.
methodsUsing the Athero-Express biobank, atherosclerotic plaques of 1277 consecutive patients undergoing carotid endarterectomy included between 2010 and 2021 were analyzed to examine time-dependent changes in histological plaque characteristics in intervals of 2 years. These results were compared with our previous time-dependent plaque composition data between 2002 and 2011 consisting of 1660 patients.
resultsIn contrast with the period 2002 through 2011, the period 2010 through 2021 showed a significant increase in vulnerable plaque characteristics: large lipid cores, intraplaque hemorrhage, macrophages, and calcification. When adjusted for confounders related to these plaque characteristics, such as time to operation and preoperative type of symptoms, the adjusted odds ratios per 2-year increase in time were 1.204 (95% CI, 1.090-1.331;
conclusionsOur study did not support a further increase in plaque-stabilizing features in carotid atherosclerotic plaques between 2010 and 2021. In contrast, plaques even showed features of destabilization in the present cohort.
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