Evidence map›Paper›PMID 41025355›Full record

ArticleeLife2025

Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants.

Balázs István Tóth, Bahar Bazeli, Annelies Janssens, Erika Lisztes, Márk Racskó, Balázs Kelemen, Mihály Herczeg, Tamás Milán Nagy, Katalin E Kövér, Argha Mitra and 3 more

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Balázs István Tóth *Laboratory of Cellular and Molecular Physiology, Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.ORCID https://orcid.org/0000-0002-4103-4333
Bahar Bazeli *Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, Leuven, Belgium.ORCID https://orcid.org/0000-0001-9568-2689
Annelies JanssensLaboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, Leuven, Belgium.
Erika LisztesLaboratory of Cellular and Molecular Physiology, Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Márk RacskóLaboratory of Cellular and Molecular Physiology, Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Balázs KelemenLaboratory of Cellular and Molecular Physiology, Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Mihály HerczegDepartment of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary.ORCID https://orcid.org/0000-0002-7938-9789
Tamás Milán NagyMTA-DE Molecular Recognition and Interaction Research Group, University of Debrecen, Debrecen, Hungary.
Katalin E KövérMTA-DE Molecular Recognition and Interaction Research Group, University of Debrecen, Debrecen, Hungary.
Argha MitraLaboratory of Chemical Biology, Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, Hungary.
Attila BoricsLaboratory of Chemical Biology, Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, Hungary.ORCID https://orcid.org/0000-0002-6331-3536
Tamás BíróDepartment of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Thomas VoetsLaboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, Leuven, Belgium.ORCID https://orcid.org/0000-0001-5526-5821

Funding

Fonds Wetenschappelijk Onderzoek G0B9520NH2020 Marie Skłodowska-Curie Actions 10.3030/955643Horizon 2020 Framework Programme 10.3030/739593Innovációs és Technológiai Minisztérium ÚNKP-21-5-DE-491Innovációs és Technológiai Minisztérium ÚNKP-22-3-I-DE-324Innovációs és Technológiai Minisztérium UNKP-22-4-I-DE-87Innovációs és Technológiai Minisztérium ÚNKP-23-3-II-DE-430KU Leuven C2-TRPKU Leuven Research Council AKUL/19/34Magyar Tudományos Akadémia János Bolyai Research ScholarshipNational Research, Development and Innovation Office 134725National Research, Development and Innovation Office 134791National Research, Development and Innovation Office 137924National Research, Development and Innovation Office GINOP-2.3.2-15-2016-00044National Research, Development and Innovation Office GINOP-2.3.2-15-2016-00050National Research, Development and Innovation Office GINOP-2.3.3-15-2016-00004
6 · The paper itself

Abstract

Rapamycin (sirolimus), a macrolide compound isolated from the bacterium

Indexed as

Immunosuppressive AgentsSirolimusTRPM Cation ChannelsBinding SitesHEK293 CellsHumansMolecular Docking SimulationProtein BindingImmunosuppressive AgentsSirolimusTRPM8 protein, humanTRPM Cation Channelshumanion channel gatingmouseneuroscienceRapamycinstructure-functionTRP ion channelsTRPM8

Identifiers

PMID41025355
PMCPMC12483518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.