ArticleeLife2025
A drug repurposing approach reveals targetable epigenetic pathways in
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Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
–field-weighted citation impact
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- New thinking for the next generation of antimalarials.EMBO molecular medicine · 2026Review
- MaRNAV-1, an intracellular virus ofbioRxiv : the preprint server for biology · 2026Article
- Epigenetics and chromatin structure regulateeLife · 2026Article
- Host kinase regulation of Plasmodium vivax dormant and replicating liver stages.PLoS neglected tropical diseases · 2026Article
- Epigenetics and chromatin structure regulatebioRxiv : the preprint server for biology · 2026Article
- Article
- Hybrid Molecules as Efficient Drugs against Multidrug-Resistant Malaria Parasites.ChemMedChem · 2025Review
- HaloPROTAC3 does not trigger the degradation of the halotagged parasitophorous vacuole membrane protein UIS4 during Plasmodium liver stage development.Scientific reports · 2025Article
- Novel drug candidates targetingFrontiers in pharmacology · 2025Article
- Review
- Novel hydrazone compounds with broad-spectrum antiplasmodial activity and synergistic interactions with antimalarial drugs.Antimicrobial agents and chemotherapy · 2024Article
- Histone code: a common language and multiple dialects to meet the different developmental requirements of apicomplexan parasites.Current opinion in microbiology · 2024Review
Corrections and comments
- Update of
Authors and funding
48 authors.
Steven P MaherCenter for Tropical and Emerging Global Disease, University of Georgia, Athens, United States.ORCID https://orcid.org/0000-0002-9560-5656
Malina A BakowskiCalibr, a division of The Scripps Research Institute, La Jolla, United States.ORCID https://orcid.org/0000-0002-3337-6528
Amélie VantauxMalaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia, Phnom Penh, Cambodia.ORCID https://orcid.org/0000-0002-7945-961X
Erika L FlanneryNovartis Institute for Tropical Diseases, Novartis Institutes for Biomedical Research, Emoryville, United States.ORCID https://orcid.org/0000-0003-0665-7954
Chiara AndolinaShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mae Sot, Thailand.
Mohit GuptaDepartment of Molecular, Cell, and Systems Biology, University of California, Riverside, Riverside, United States.
Yevgeniya Antonova-KochCalibr, a division of The Scripps Research Institute, La Jolla, United States.
Magdalena ArgomanizCenter for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, United States.
Monica Cabrera-MoraInternational Center for Malaria Research, Education and Development, Emory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, United States.
Brice CampoMedicines for Malaria Venture (MMV), Geneva, Switzerland.
Alexander T ChaoNovartis Institute for Tropical Diseases, Novartis Institutes for Biomedical Research, Emoryville, United States.
Arnab K ChatterjeeCalibr, a division of The Scripps Research Institute, La Jolla, United States.
Wayne T ChengCenter for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, United States.
Vorada ChuenchobNovartis Institute for Tropical Diseases, Novartis Institutes for Biomedical Research, Emoryville, United States.
Caitlin A CooperCenter for Tropical and Emerging Global Disease, University of Georgia, Athens, United States.
Karissa CottierBioIVT Inc, New York, United States.
Mary R GalinskiInternational Center for Malaria Research, Education and Development, Emory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, United States.
Anke Harupa-ChungNovartis Institute for Tropical Diseases, Novartis Institutes for Biomedical Research, Emoryville, United States.
Hana JiCenter for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, United States.
Sean B JosephCalibr, a division of The Scripps Research Institute, La Jolla, United States.
Todd LenzDepartment of Molecular, Cell, and Systems Biology, University of California, Riverside, Riverside, United States.
Stefano LonardiDepartment of Computer Science and Engineering, University of California, Riverside, Riverside, United States.
Jessica MathesonDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Sebastian A MikolajczakNovartis Institute for Tropical Diseases, Novartis Institutes for Biomedical Research, Emoryville, United States.
Timothy MoellerBioIVT Inc, New York, United States.
Agnes OrbanMalaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia, Phnom Penh, Cambodia.
Vivian Padín-IrizarryCenter for Tropical and Emerging Global Disease, University of Georgia, Athens, United States.
Kastin PanCalibr, a division of The Scripps Research Institute, La Jolla, United States.ORCID https://orcid.org/0009-0003-5838-1694
Julie PéneauMalaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia, Phnom Penh, Cambodia.
Jacques PrudhommeDepartment of Molecular, Cell, and Systems Biology, University of California, Riverside, Riverside, United States.ORCID https://orcid.org/0000-0002-6161-5194
Camille RoeschMalaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia, Phnom Penh, Cambodia.
Anthony RubertoCenter for Tropical and Emerging Global Disease, University of Georgia, Athens, United States.ORCID https://orcid.org/0000-0002-3215-9484
Saniya S SabnisCenter for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, United States.
Celia L SaneyCenter for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, United States.
Jetsumon SattabongkotMahidol Vivax Research Unit, Mahidol University, Bangkok, Thailand.ORCID https://orcid.org/0000-0002-3938-4588
Saleh SereshkiDepartment of Computer Science and Engineering, University of California, Riverside, Riverside, United States.
Sangrawee SuriyakanShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mae Sot, Thailand.
Ratawan UbaleeDepartment of Entomology, Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand.
Yinsheng WangDepartment of Chemistry, University of California, Riverside, Riverside, United States.
Praphan WasisakunShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mae Sot, Thailand.
Jiekai YinEnvironmental Toxicology Graduate Program, University of California, Riverside, Riverside, United States.
Jean PopoviciMalaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia, Phnom Penh, Cambodia.
Case W McNamaraCalibr, a division of The Scripps Research Institute, La Jolla, United States.
Chester JoynerCenter for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, United States.ORCID https://orcid.org/0000-0003-1367-2829
François H NostenShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mae Sot, Thailand.ORCID https://orcid.org/0000-0002-7951-0745
Benoît WitkowskiMalaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia, Phnom Penh, Cambodia.
Karine G Le RochDepartment of Molecular, Cell, and Systems Biology, University of California, Riverside, Riverside, United States.
Dennis E KyleCenter for Tropical and Emerging Global Disease, University of Georgia, Athens, United States.ORCID https://orcid.org/0000-0002-0238-965X
Funding
Hit-to-Lead Development of the Kalihinol Scaffold for Malaria TreatmentR01AI138139 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI BEN MAMOUN, CHOUKRI, LE ROCH, KARINE GAELLE · 2018 to 2022
$3.6MChromatin structure and control of gene expression in the human malaria parasiteR01AI136511 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI LE ROCH, KARINE GAELLE · 2018 to 2022
$3.4MDeciphering the Role of Non-Coding RNAs in Gene RegulationR01AI188634 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Laurence Alexandra Florens, Karine Gaelle Le Roch · 2025 to 2026
$1.6MIllumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600kBill and Melinda Gates Foundation #OPP1023601Bill and Melinda Gates Foundation #OPP1107194Bill & Melinda Gates Foundation INV-031788Gates Foundation INV-031788Medicines for Malaria Venture RD/15/0022Medicines for Malaria Venture RD/17/0042NIAID NIH HHS HHSN272201200031CNIAID NIH HHS R01 AI136511NIAID NIH HHS R01 AI138139NIAID NIH HHS R01 AI188634NIH HHS 1R01 AI136511NIH HHS #HHSN272201200031CNIH HHS S10 OD026929University of California, Riverside #NIFA-Hatch-225935Wellcome Trust
Abstract
Radical cure of
Indexed as
AntimalarialsDrug RepositioningEpigenesis, GeneticPlasmodium vivaxDNA MethylationHumansMalaria, VivaxSporozoitesAntimalarialsbiochemistrychemical biologyDNA methylationhypnozoitesinfectious diseasemalariamicrobiologyP. cynomolgiP. falciparumPlasmodium cynomolgiPlasmodium vivaxprimary hepatocytesP. vivaxrhesus macaque
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.