Evidence map›Paper›PMID 41025172›Full record

ArticleJournal of diabetes investigation2025

Longitudinal changes in cognitive function and its related factors in older type 1 diabetes mellitus patients without dementia.

Kaoru Nagasawa, Kimio Matsumura, Takayasu Uchida, Yuya Suzuki, Akihiro Nishimura, Yukifusa Igeta, Takashi Sakurai, Yasumichi Mori

Abstract read
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In one paragraph

Article in Journal of diabetes investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kaoru NagasawaDepartment of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.ORCID https://orcid.org/0009-0002-3135-8964
Kimio MatsumuraDepartment of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.
Takayasu UchidaDepartment of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.
Yuya SuzukiDepartment of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.
Akihiro NishimuraOkinaka Memorial Institute for Medical Research, Tokyo, Japan.ORCID https://orcid.org/0000-0002-9347-1228
Yukifusa IgetaDepartment of Dementia, Toranomon Hospital, Tokyo, Japan.
Takashi SakuraiDepartment of Prevention and Care Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan.
Yasumichi MoriDepartment of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.

Funding

Research Funding for Longevity Science from the National Center for Geriatrics and Gerontology
6 · The paper itself

Abstract

aimsThis study aimed to assess the longitudinal changes in cognitive function and associated factors in older patients with type 1 diabetes mellitus without dementia. MATERIALS AND

methodsOlder patients above 65 years of age with type 1 diabetes mellitus and without dementia were included in this study. They were assessed using the Mini-Mental State Examination and Montreal Cognitive Assessment, Japanese version, at baseline and 3 years after. Cognitive decline was defined as a reduction of two or more points in the total Montreal Cognitive Assessment score over 3 years. Baseline diabetes-related factors were compared between the cognitive decrement and non-decrement groups to identify risk factors associated with cognitive impairment.

resultsTwenty-eight patients aged 71.5 ± 4.0 years were included. Total scores for the Mini-Mental State Examination and the Montreal Cognitive Assessment (Japanese version) at baseline and after 3 years of follow-up showed no significant changes (P = 0.38, P = 0.26). Delayed recall sub-scores of both tests were significantly lower after 3 years compared to their corresponding levels at baseline (P = 0.007, P = 0.04); 32% experienced impaired cognition after 3 years compared to baseline examination. Decline in total Montreal Cognitive Assessment score was significantly associated with the onset age (β = 0.54, P = 0.026) and duration of type-1 diabetes mellitus (β = -4.77, P = 0.026).

conclusionsPatients with type-1 diabetes mellitus without dementia experience a progressive decline in memory over time. Long durations of type-1 diabetes mellitus are associated with cognitive decline even without dementia.

Indexed as

CognitionCognitive DysfunctionDementiaDiabetes Mellitus, Type 1AgedAged, 80 and overFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMental Status and Dementia TestsNeuropsychological TestsPrognosisRisk FactorsCognitionMontreal Cognitive AssessmentType 1 diabetes

Identifiers

PMID41025172
PMCPMC12679171

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.