ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2025
Integrating Astrocytes in the Sleep-Wake Cycle: The Time Is Now.
Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A High-Throughput Live Imaging Platform to Investigate Circuit-Dependent Regulation of Circadian Rhythms in Brain Tissue.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Integrating Astrocytes in the Sleep-Wake Cycle: The Time Is Now.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Astrocytes are emerging as critical regulators of the sleep-wake cycle, actively contributing to both sleep homeostasis and circadian rheostasis. This dual role challenges neuron-centric frameworks that have dominated sleep and circadian biology and highlights astrocytes as potential integrators of internal temporal information. Experimental evidence shows that astrocytic calcium dynamics correlate with sleep state and that manipulating astrocytes can alter sleep architecture and homeostasis. In parallel, key aspects of circadian timekeeping can be autonomously driven by astrocytic clocks, with pulses of rhythmic GABA and glutamate able to synchronize circadian circuits and support circadian patterns of behavior. These findings are coherent with the idea that astrocytes can act as context-dependent integrators to convey environmental cues and internal states to neuronal circuitries and promote adaptive behavior. Incorporating astrocytes into conceptual models of the sleep-wake cycle may help reconcile contradictory findings and offer new frameworks to better understand how salient internal temporal representations are encoded within the brain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.