ArticleFood safety (Tokyo, Japan)2025
Targeting Mitochondria to Inhibit Aflatoxin Production: Mechanistic Insight.
Article in Food safety (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Contamination of agricultural crops by aflatoxin, a potent carcinogenic fungal toxin, is a global issue that poses serious health risks to humans and livestock while inflicting significant economic damage on the agricultural sector. Specific inhibitors of aflatoxin production hold promise not only as effective agents for controlling aflatoxin contamination, but also as valuable tools for uncovering the regulatory mechanisms of secondary metabolism through the elucidation of their modes of action. Unexpectedly, inhibitors whose modes of action we have clarified were found to target mitochondrial components, rather than proteins directly involved in the aflatoxin biosynthetic pathway. In this article, we review inhibitors and inhibitory mixtures that act on mitochondria and explore the relationship between mitochondrial function and aflatoxin production through their modes of action.
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