Evidence map›Paper›PMID 41025091›Full record

ArticleWorld journal of virology2025

Uptake and disparities in tuberculosis screening using urine-lipoarabinomannan among patients with advanced human immunodeficiency virus-disease in Africa: A systematic review.

Lynn Moshi, Hafidha Mhando Bakari, Jackline Vicent Mbishi, Zuhura Mbwana Ally, Mariam Salim Mbwana, Haji Mbwana Ally, Rahma Musoke, Swalehe Mustafa Salim, Maximillian Francis Karia, Leticia Francis Karia and 4 more

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Article in World journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Lynn MoshiDepartment of Obstetrics and Gynecology, Aga Khan Hospital, Dar es Salaam 14112, Tanzania.
Hafidha Mhando BakariDepartment of Literature, Communication and Publishing, University of Dar es Salaam, Dar es Salaam 16103, Tanzania.
Jackline Vicent MbishiDepartment of Epidemiology and Biostatistics, Muhimbili University of Health and Allied Sciences, Dar es Salaam 11102, Tanzania.
Zuhura Mbwana AllyDepartment of Medicine, District Hospital, Tanga 21628, Tanzania.
Mariam Salim MbwanaDepartment of Medicine, Primary Health Care Institute, Iringa 51108, Tanzania.
Haji Mbwana AllyDepartment of Medicine, Kilimanjaro Christian Medical Center, Moshi 25116, Kilimanjaro, Tanzania.
Rahma MusokeDepartment of Research, Water Mission, Dar es Salaam 14112, Tanzania.
Swalehe Mustafa SalimDepartment of Research, Canada Youth Group, Dar es Salaam 15103, Tanzania.
Maximillian Francis KariaDepartment of Research, The Greenfield School at Wilson, North Carolina, Wilson, NC 27893, United States.
Leticia Francis KariaDepartment of Research, Appalachian State University, Boone, NC 28608, United States.
Hassan Fredrick FussiDepartment of Medicine, District Hospital, Tanga 21628, Tanzania.
Aboubakar Omar MustafaDepartment of Pharmacy, Tanga Regional Referral Hospital, Tanga 21101, Tanzania.
Ibrahim Ahmed El-LmamDepartment of Epidemiology, University of Maryland School of Medicine, Baltimore, MD 21201, United States.
Habib Omari RamadhaniDepartment of Medicine, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, United States. homari@ihv.umaryland.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDue to low bacteria count and high likelihood of having extrapulmonary tuberculosis (TB) among patients with advanced human immunodeficiency virus (HIV) disease, the World Health Organization (WHO) recommended the use of urine lateral flow urine lipoarabinomannan (LF-LAM) or sputum-Xpert to screen for TB.

aimTo estimate pooled prevalence of TB screening uptake, TB diagnosis, TB treatment initiation and mortality among patients with advanced HIV disease in Africa.

methodsPubMed, Cochrane Library and EMBASE were searched for articles published between January 2011 and December 2024. TB screening uptake was defined as percentage of patients with advanced HIV disease (CD4 ≤ 200 cells/mm

resultsA total of nineteen studies with 16065 people with advanced HIV disease were analyzed. The pooled prevalence of TB screening uptake was 64.6% (95%CI: 49.2-80.1). The pooled prevalence of TB was 29.4% (95%CI: 22.0-36.8), and TB treatment initiation was 77.9% (95%CI: 63.9-91.8), and mortality was 19.5% (95%CI: 8.9-30.0). The pooled prevalence of TB testing uptake was significantly lower among children compared to adults (28.2%

conclusionFour in ten people with advanced HIV disease were not screened for TB as recommended by the WHO, indicating significant gaps in identifying patients with TB. Excluding patients with evidence of TB is critical to avoid exposing them to subtherapeutic levels of anti TB treatment.

Indexed as

AfricaMortalityTuberculosis prevalenceTuberculosis testing uptakeUrine lateral flow lipoarabinomannan

Identifiers

PMID41025091
PMCPMC12476789

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.