Evidence map›Paper›PMID 41025090›Full record

ReviewWorld journal of virology2025

Gut microbiome and viral infections: A hidden nexus for immune protection.

Ajay M Gavkare, Neeta L Nanaware, Mahesh N Sonar, Shree V Dhotre, Sachin S Mumbre, Basavraj S Nagoba

Abstract readReview
In one paragraph

Review in World journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ajay M GavkareDepartment of Physiology, Government Medical College, Buldhana 443001, Maharashtra, India.
Neeta L NanawareDepartment of Physiology, Vilasrao Deshmukh Government Medical College, Latur 413512, Maharashtra, India.
Mahesh N SonarDepartment of Pediatrics, Maharashtra Institute of Medical Sciences and Research (Medical College), Latur 413531, Maharashtra, India.
Shree V DhotreDepartment of Microbiology, Ashwini Rural Medical College, Solapur 413001, Maharashtra, India.
Sachin S MumbreDepartment of Community Medicine, Ashwini Rural Medical College, Solapur 413006, India.
Basavraj S NagobaDepartment of Microbiology, Maharashtra Institute of Medical Sciences and Research (Medical College), Latur 413531, Maharashtra, India. dr_bsnagoba@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiome plays a crucial role in regulating immune responses, influencing susceptibility to viral infections, shaping disease progression, and its outcomes. Emerging research highlights the intricate relationship between gut microbial communities and viral pathogenesis, demonstrating that dysbiosis can compromise antiviral defenses while a balanced microbiome enhances immune resilience. This review explores key microbial mechanisms, including microbiome-mediated immune modulation, interactions with viral replication, and the impact of microbiome on systemic inflammation, highlighting how dietary interventions, such as probiotics, prebiotics, and bioactive compounds, offer potential strategies to modulate gut microbiota and mitigate viral infections. Special emphasis is placed on viruses affecting the gastrointestinal and respiratory systems, including severe acute respiratory syndrome coronavirus 2, norovirus, and influenza. Furthermore, we explore how nutrition-driven microbiome interventions may serve as adjunct therapeutic strategies, improving vaccine efficacy and post-viral recovery. Understanding the role of gut microbiome in viral infections can pave the way for microbiome-driven strategies to combat viral diseases and improve overall health outcomes.

Indexed as

DysbiosisGut microbiotaImmune protectionInnate immunityMicrobiome-derived metabolitesShort-chain fatty acidsViral infectionsVirome

Identifiers

PMID41025090
PMCPMC12476802

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.