Evidence map›Paper›PMID 41025041›Full record

ArticleInfection and drug resistance2025

Evaluating Chelerythrine Chloride as a Potential Treatment for Multidrug-Resistant Gonorrhea.

Ran Zhang, Yuqiu Qi, Hui Peng, Chenlong Tao, Songwei Lu, Qiankun Ke, Shangzhu Shen, Zhuo Wang, Xiaomian Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ran Zhang *Department of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, People's Republic of China.
Yuqiu Qi *Department of Pharmacy, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China.
Hui Peng *Department of Pharmacy, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China.
Chenlong TaoDepartment of Pharmacy, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China.
Songwei LuDepartment of Pharmacy, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China.
Qiankun KeDepartment of Pharmacy, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China.
Shangzhu ShenDepartment of Pharmacy, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China.
Zhuo WangDepartment of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, People's Republic of China.
Xiaomian LinDepartment of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Methods: A total of 54 clinical strains of Results: In clinical samples, antimicrobial resistance was observed for penicillin (67.27%), tetracycline (81.82%), ciprofloxacin (98.18%), azithromycin (5.45%), and spectinomycin (0%), with decreased susceptibility for ceftriaxone (16.36%) and cefixime (20.00%). High-throughput screening of a natural product library identified chelerythrine chloride as exhibiting significant inhibitory activity against Conclusion: In this study, we have established a novel association between chelerythrine chloride and

Indexed as

antimicrobial agentantimicrobial resistancechelerythrine chlorideN. gonorrhoeae

Identifiers

PMID41025041
PMCPMC12476847

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.