Evidence map›Paper›PMID 41025036›Full record

ArticleOxford medical case reports2025

Salt-losing syndrome as a mimicker of the Nephroprotective effect of Gliflozins in Proteinuric nephropathies.

Giulio Romano, Fiorini Nicholas, Gianluca Colussi

Abstract readCase Reports
In one paragraph

Article in Oxford medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Giulio RomanoDepartment of Medical Area, University of Udine, Via Colugna 50, 33100 Udine, Italy.ORCID https://orcid.org/0000-0002-3051-7612
Fiorini NicholasDepartment of Medical Area, University of Udine, Via Colugna 50, 33100 Udine, Italy.ORCID https://orcid.org/0009-0002-3735-8252
Gianluca ColussiDivision of Internal Medicine, Department of Medical Sciences, University of Ferrara, Via Fossato di Mortara, 64/B, 44121 Ferrara, Italy.ORCID https://orcid.org/0000-0003-1673-540X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gliflozins are oral antidiabetic drugs associated with a direct nephroprotective effect. Their administration reduces glomerular hyperfiltration and proteinuria by activating the tubule-glomerular feedback through an increased sodium delivery to the macula densa. We hypothesized a similar mechanism for nephroprotection in a patient with limited proteinuria, despite long-lasting glomerular damage secondary to suspected focal segmental glomerulosclerosis in a solitary kidney who also had salt-losing nephropathy.

Indexed as

fractional excretion of sodiumgliflozinsproteinuriaproximal salt losing nephropathytubulo-glomerular feedback

Identifiers

PMID41025036
PMCPMC12476549

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.