ReviewGastroenterology report2025
Long non-coding RNAs promote colorectal cancer development through other epigenetic modifications.
Review in Gastroenterology report, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Targeting lncRNA DSCAM-AS1 for disease diagnosis and therapy.Non-coding RNA research · 2026Review
- Small nucleolar RNA host genes in hepatocellular carcinoma: an evidence-weighted and etiology-aware framework for mechanistic and translational interpretation.Molecular biology reports · 2026Review
- Signals in Peripheral Blood: Tracking Redox Status and DNA Damage Response During the Progression of Multiple Myeloma.International journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer is one of the most prevalent malignant tumors worldwide, and it has one of the highest rates of mortality and morbidity. Its emergence and progression are intricately linked to various genetic and epigenetic factors influencing colonic epithelial cells. Long non-coding RNAs function as crucial regulators of the epigenetic landscape, playing significant roles in the development, progression, invasion, metastasis, and drug resistance of various tumors, particularly colorectal cancer. Epigenetic modifications, such as DNA methylation, RNA methylation, and histone modification, facilitate heritable gene expression regulation without changing the underlying DNA sequence. Recent studies have increasingly highlighted the intricate interactions between lncRNAs and these epigenetic modifications in colorectal cancer, illuminating their participation in critical processes, including cell proliferation, apoptosis, invasion, and metastasis. This review concentrates on the relationship between long non-coding RNAs and several significant epigenetic modifications that drive colorectal cancer development, offering fresh insights for future research that aims at devising more effective treatment strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.