ArticleCureus2025
Diagnostic Dilemmas in Cardiac Transthyretin Amyloidosis With Coexistent Low-Grade B-Cell Lymphoma: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac amyloidosis, though a rare clinical entity, is increasingly recognized as an important etiology of heart failure and cardiac arrhythmias. The deposition of misfolded amyloid fibrils in the myocardium leads to restrictive cardiomyopathy and progressive cardiac dysfunction. Two main precursor proteins are implicated in cardiac amyloidosis: transthyretin (TTR), synthesized by the liver, and immunoglobulin light chain (AL), usually associated with plasma cell dyscrasias and lymphomas. Given the substantial differences in treatment and prognosis between TTR and AL amyloidosis, accurate differentiation between these subtypes is critical for delivering optimal patient care. We report the case of a 64-year-old man with progressive dyspnea and atrial flutter who was found to have severe concentric left ventricular hypertrophy and a characteristic "cherry on top" strain pattern on echocardiography. A technetium-99m pyrophosphate (PYP) scan demonstrated grade 3 uptake, but a concurrent abnormal IgM spike on serum electrophoresis prompted further hematologic evaluation. Bone marrow biopsy revealed a low-grade B-cell lymphoma without amyloid deposition, while endomyocardial biopsy with mass spectrometry confirmed wild-type TTR amyloidosis. The patient underwent atrial flutter ablation and was initiated on tafamidis with clinical improvement. To our knowledge, this represents the first reported case of coexisting ATTR cardiac amyloidosis and B-cell lymphoma diagnosed simultaneously. This case highlights the diagnostic challenges when hematologic malignancy and cardiac amyloidosis coexist, underscores the importance of endomyocardial biopsy for definitive typing, and emphasizes the role of a multidisciplinary approach in guiding management and optimizing outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.