Evidence map›Paper›PMID 41024880›Full record

ReviewWorld journal of hepatology2025

Re-evaluating surgical strategies in Barcelona Clinic Liver Cancer-B hepatocellular carcinoma.

Ioannis Liapis, Ioannis A Ziogas, Charalampos Theocharopoulos, Dimitrios P Moris, Trevor L Nydam, Ana L Gleisner, Richard D Schulick, Georgios Tsoulfas

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ioannis LiapisDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, United States.
Ioannis A ZiogasDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States.
Charalampos TheocharopoulosDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States.
Dimitrios P MorisMedStar Georgetown Transplant Institute, MedStar Washington Hospital Center, Washington, WA 20007, United States.
Trevor L NydamDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States.
Ana L GleisnerDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States.
Richard D SchulickDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States.
Georgios TsoulfasDepartment of Transplantation Surgery, Center for Research and Innovation in Solid Organ Transplantation, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki 54642, Greece. tsoulfasg@auth.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of hepatocellular carcinoma (HCC) has been steadily rising, underscoring the need for a clear, stage-specific treatment approach. The Barcelona Clinic Liver Cancer (BCLC) staging system remains the most widely used framework for classifying HCC and guiding therapy. Among its classifications, the intermediate stage (BCLC-B) encompasses a highly heterogeneous patient population, with varying degrees of tumor burden and liver function. Traditionally, transarterial chemoembolization has been the standard treatment for this stage, based on earlier evidence. However, recent studies suggest that a subset of BCLC-B patients-particularly those with localized disease-may benefit more from liver resection. This review summarizes current treatment paradigms for BCLC-B HCC, explores emerging subclassifications within this group, and highlights evolving guidelines that support the selective use of surgery in appropriately chosen patients.

Indexed as

Barcelona Clinic Liver CancerGuidelinesHepatocellular carcinomaMinireviewSurgical resection

Identifiers

PMID41024880
PMCPMC12476717

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.