ArticleJournal of sickle cell disease2025
Clinical phenotype of high-impact chronic pain in sickle cell disease at consultation for hematopoietic cell transplant.
Article in Journal of sickle cell disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction/Objective: Lack of a well-characterized phenotype of High-Impact Chronic pain (HICP), that is, chronic pain (CP) with substantial restriction of participation in work, social, or self-care activities remains a critical gap in identifying individuals with CP and SCD at-risk for poor pain outcomes. Methods: Retrospective study using the Electronic Health Record (EHR) at a large academic children's hospital. Results: We report the clinical phenotype of 46 children with SCD diagnosed with HICP at time of consultation for Hematopoietic Cell Transplant (HCT). The mean age was 14.5 years (SD 3.9), 50% ( Conclusion: HICP in SCD is associated with substantial morbidity. This study underscores the importance of screening for HICP in SCD.
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