ArticleWorld journal of gastrointestinal surgery2025
Gallstone and bile microbiota: A case-control study based on 16S rRNA gene sequencing.
Article in World journal of gastrointestinal surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundGallstone (GS), a prevalent biliary disorder, is associated with bile stasis, infection, and cholesterol metabolism. Recent research highlights the potential role of bile microbiota in GS pathogenesis. This is a case control study conducted at Jinshan Hospital between 2022 and 2023.
aimTo investigate the relationship between bile microbiota dysbiosis and GS formation, and analyze bile microbiota composition in GS patients.
methodsThis is a retrospective analysis conducted at Jinshan Hospital between 2022 and 2023. A total of 40 patients were analyzed, including 25 with GS and 15 with GS-free (GSF). Bile samples from 27 patients were analyzed using 16S rRNA gene sequencing to assess microbial composition.
resultsSignificant differences were found in bile acid profiles between GS and GSF groups, with lower microbial diversity in GS patients, indicated by reduced Shannon, Chao, Ace, and Sobs indices, and a higher Simpson index. At the phylum level, the most abundant taxa in GS patients were
conclusionDysbiosis, particularly overgrowth of
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