ArticleWorld journal of gastrointestinal surgery2025
Evaluation of pathological findings in predicting postoperative endoscopic recurrence in Crohn's disease: A retrospective cohort study.
Article in World journal of gastrointestinal surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCrohn's disease (CD) patients with intestinal involvement often require surgical intervention due to resistance to medical therapy. Postoperative recurrence remains a significant challenge, with the Rutgeerts score commonly used to predict endoscopic recurrence.
aimTo evaluate the relationship between microscopic and macroscopic pathological findings in resected intestinal specimens and the Rutgeerts score to predict endoscopic recurrence in CD patients.
methodsThis retrospective cohort study included 32 patients over 18 years of age with intestinal CD who underwent surgery at General Surgery Clinic of Ankara Bilkent City Hospital between November 2019 and October 2023. Resection specimens were histopathologically re-examined, and postoperative colonoscopy reports were classified according to the Rutgeerts score. The association between pathological findings and endoscopic recurrence was analyzed statistically.
resultsNo significant association was found between macroscopic findings and Rutgeerts scores or endoscopic recurrence (
conclusionThe presence of neutrophilic cryptitis and crypt abscesses in resected intestinal specimens of CD patients increases the likelihood of endoscopic recurrence. Early postoperative medical treatment and close endoscopic follow-up may benefit high-risk patients to prevent recurrence, with treatment decisions made by a weekly multidisciplinary council involving General Surgery, Gastroenterology, and Radiology.
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