ArticleWorld journal of gastrointestinal surgery2025
Effects of preoperative immunonutrition
Article in World journal of gastrointestinal surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of immunonutrition on postoperative ileus following colorectal cancer surgery: a systematic review and meta-analysis of randomized controlled trials.Frontiers in nutrition · 2026Pooled it
- Nutritional prehabilitation strategies in abdominal surgery.Current opinion in clinical nutrition and metabolic care · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrent guidelines recommend providing malnourished individuals immunonutrition before major gastrointestinal surgery. Nonetheless, the advantages of preoperative immunonutrition remain controversial.
aimTo analyses the effects of preoperative immunonutrition and standard oral nutrition supplements on colorectal surgery outcomes.
methodsThis study employed a prospective single-center randomized double-blinded comparative approach and was conducted at Hospital Universiti Sains Malaysia between September 2023 and September 2024. In this study, the participants in the experimental group were supplied with a specialized oral supplement enriched with immune-modulating nutrients. Meanwhile, a conventional oral nutrition supplement was provided to the control group. The time to first flatus and the time to first bowel evacuation were the primary outcomes recorded. Incidence of nosocomial infections, surgical site infections, and the total length of hospital stay were considered secondary data.
resultsThis study involved 58 patients who were allocated into two groups. No dropouts were documented. The mean age of the participants was 61.20 ± 12.96, and most were males (63.38%). All participants' baseline and surgical characteristics in both arms were also generally comparable. The participants in this study underwent colorectal surgery, where most had laparoscopic surgery (58%). Based on the results, no significant statistical differences were observed regarding the duration from the first flatus to the first bowel evacuation, the onset of a normal diet, and hospital stay between the experimental and control groups. Both groups also recorded 10 (17.24%) infectious complications.
conclusionThe findings indicated no notable variations in the primary and secondary endpoints despite the theoretical benefits of immune-modulating nutrients. Conclusively, routine preoperative immunonutrition may not provide additional advantages over standard nutrition in this demographic.
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