ReviewWorld journal of gastroenterology2025
From bench to bedside: Advancements in patient-derived xenografts for predicting therapy outcomes in colorectal cancer.
Review in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer is the third most diagnosed malignancy and the second-leading cause of cancer-related deaths worldwide. Management includes a combination of surgery, radiotherapy, and systemic therapy that is tailored to the stage of the disease. However, each tumor has a unique genetic profile that influences the treatment response and the overall prognosis. Biomarkers guide treatment decisions, but many chemotherapeutics lack reliable predictors. To bridge this gap patient-derived xenograft models were developed and are valuable preclinical tools. These systems utilize patient-derived tumor tissue grafted into an animal host that provides a platform for personalized drug profiling. This article surveyed recent advances in mouse and zebrafish colorectal cancer patient-derived xenografts, emphasizing their clinical utility for functional precision oncology. We explored the impact of these models on translational research, discussed current limitations, and outlined key priorities for future development.
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