Evidence map›Paper›PMID 41024699›Full record

ReviewTransfusion2025

The whole is greater than the sum of its parts: Rethinking our approach to neonatal transfusion research.

Nina A M Houben, Camila Caram-Deelder, Enrico Lopriore, Suzanne Fustolo-Gunnink, INSPIRE contributors

Abstract readReview
In one paragraph

Review in Transfusion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nina A M HoubenDivision of Neonatology, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, the Netherlands.ORCID https://orcid.org/0000-0001-7605-4927
Camila Caram-DeelderDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.ORCID https://orcid.org/0000-0003-3161-5684
Enrico LoprioreDivision of Neonatology, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, the Netherlands.
Suzanne Fustolo-GunninkDivision of Neonatology, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, the Netherlands.
INSPIRE contributors

Funding

European Blood Alliance EBA Grant Agreement 2021-02European Society for Paediatric Research, ESPR Post-Doc Research Grant 2020Stichting Sanquin Bloedvoorziening PPOC21-08/ L2588Stichting Sanquin Bloedvoorziening RES/00264
6 · The paper itself

Abstract

Many preterm infants are exposed to multiple transfusion types during their admission in the neonatal intensive care unit. Yet, evidence supporting current practice consists of several randomized controlled trials and observational studies focusing on a single transfusion product at the time. Rather than approaching transfusions as three distinct categories as currently done in the literature, there may be benefit by accounting for the interconnected nature of these practices. In this Clinical Research Focus article, we advocate for a broader perspective in future research on neonatal transfusion practices. By looking at the whole instead of its parts, we can gain a more comprehensive understanding of the impact of transfusion exposure, potential associated adverse effects, and their implications for neonatal care.

Indexed as

Biomedical ResearchBlood TransfusionHumansInfant, NewbornInfant, PrematureIntensive Care Units, NeonatalTransfusion Reactionplatelet transfusionRBC transfusiontransfusion practices

Identifiers

PMID41024699
PMCPMC12618897

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.