Evidence map›Paper›PMID 41024698›Full record

ArticleAnnals of laboratory medicine2026

Clonal Burden, Immunoglobulin Heavy Chain Variable Gene Somatic Hypermutations, and Immunoglobulin Gene Repertoire in Korean Patients with Chronic Lymphocytic Leukemia Assessed by Next-generation Sequencing.

Taegeun Lee, Daehyun Chu, Miyoung Kim, Young-Uk Cho, Sang-Hyun Hwang, Jung-Hee Lee, Dok Hyun Yoon, Hyungwoo Cho, Seongsoo Jang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of laboratory medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Taegeun LeeDepartment of Laboratory Medicine, Dongguk University Ilsan Hospital, Goyang, Korea.ORCID https://orcid.org/0000-0003-1422-4964
Daehyun ChuDepartment of Laboratory Medicine, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-9086-8740
Miyoung KimDepartment of Laboratory Medicine, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-8903-5044
Young-Uk ChoDepartment of Laboratory Medicine, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-4403-8989
Sang-Hyun HwangDepartment of Laboratory Medicine, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-3201-5728
Jung-Hee LeeHematology Section, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-3127-0068
Dok Hyun YoonDepartment of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-8289-3548
Hyungwoo ChoDepartment of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-4307-2795
Seongsoo JangDepartment of Laboratory Medicine, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-0045-1747

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: We compared the immunoglobulin ( Methods: Next-generation sequencing (NGS)-based gene rearrangements and Results: Clonal Conclusions: NGS may underestimate CLL clonal size, particularly when using the

Indexed as

Immunoglobulin Heavy ChainsImmunoglobulin Variable RegionLeukemia, Lymphocytic, Chronic, B-CellAdultAgedAged, 80 and overAsian PeopleFemaleFlow CytometryHigh-Throughput Nucleotide SequencingHumansIn Situ Hybridization, FluorescenceKaryotypingMaleMiddle AgedMutationImmunoglobulin Heavy ChainsImmunoglobulin Variable RegionChronic lymphocytic leukemiaImmunoglobulin genesImmunoglobulin heavy chainNext-generation sequencingSomatic hypermutation

Identifiers

PMID41024698
PMCPMC12915379

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.