ArticleBrain and behavior2025
Alterations in Region-Specific Gray Matter Volume Underlying Callous Unemotional Traits in Adolescents.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Source-based morphometry analyses yield associations between large-scale structural brain networks and psychopathic traits in incarcerated adolescents.Frontiers in psychology · 2026Article
- Alterations in Region-Specific Gray Matter Volume Underlying Callous Unemotional Traits in Adolescents.Brain and behavior · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundCallous-unemotional (CU) traits during adolescence, for example, shallow affect or lack of remorse, have been shown to be a risk marker for antisocial behavior. Only a few studies have investigated structural brain alterations underlying CU traits, and findings are inconclusive. The study examines CU symptomatology and gray matter volume (GMV) associations.
methodsStructural brain MRI data were collected from a sample of 578 adolescents (60% male) with a mean age of 14.85 years (SD = 2.30; range = 10-19 years). CU traits were indexed via the Inventory for Callous Unemotional Traits (ICU). Region-wise volumetric parameters were obtained following parcellation of the brain into 68 cortical and 14 subcortical regions per participant. A multiple linear regression was conducted using age, sex, IQ, intracranial volume, and handedness as covariates to assess the relationship between ICU scores and GMV.
resultsOur regression analysis showed significance (R
conclusionsUtilizing a transdiagnostic sample of adolescents, our study found significant associations between CU traits and GMV. Understanding the neurobiological associations of CU traits could be crucial for early intervention and targeted treatments, particularly for those at risk of antisocial behavior.
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