Evidence map›Paper›PMID 41024509›Full record

ArticleMagnetic resonance in medicine2026

T

Naman Jain, Saskia Bollmann, Kai-Hsiang Chuang, Jonathan R Polimeni, Markus Barth

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. TMagnetic resonance in medicine · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Naman JainQueensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia.ORCID 0000-0002-6857-2035
Saskia BollmannSchool of Electrical Engineering and Computer Science, The University of Queensland, St Lucia, Queensland, Australia.ORCID 0000-0001-8242-8008
Kai-Hsiang ChuangQueensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia.ORCID 0000-0002-8356-0657
Jonathan R PolimeniAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.ORCID 0000-0002-1348-1179
Markus BarthCentre for Advanced Imaging, The University of Queensland, St Lucia, Queensland, Australia.ORCID 0000-0002-0520-1843

Funding

Improving Human fMRI through Modeling and Imaging Microvascular Dynamics: Administrative SupplementR01MH111419 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI POLIMENI, JONATHAN RIZZO · 2016 to 2020
$4.9M
An acquisition and reconstruction framework to enable mesoscale human fMRI on clinical 3 Tesla scannersR01EB033206 · NIBIB · STANFORD UNIVERSITY · PI SETSOMPOP, KAWIN · 2022 to 2022
$853k
BRAIN Initiative R01-MH111419National Health and Medical Research Council APP1117020NIBIB NIH HHS R01 EB033206NIMH NIH HHS R01 MH111419
6 · The paper itself

Abstract

purposeThis study aims to investigate the feasibility of using T

methodThe study involved scanning of nine mice after administration of iron oxide-based superparamagnetic contrast agent via the tail vein. Two functional imaging experiments were conducted: one to investigate the effect of TE on the functional response, and another to characterize the impact of higher resolution on UTE functional contrast. Regions of interest were defined in the parenchyma and pial surface of the visual cortex.

resultsThe administration of the contrast agent produced a bright-blood signal in the vasculature in structural MRI when using a UTE acquisition. Positive signal changes were observed at the shortest TE (0.164 ms) in voxels sampling both the parenchyma (0.22% ± 0.08%) and pial surface (0.26% ± 0.1%), providing evidence that UTE fMRI experiments can detect changes in both parenchymal and pial vessels. Measurements using longer TEs (≥1 ms) showed negative signal changes, as expected. Higher spatial resolution resulted in increased percent signal change at the pial surface, suggesting reduced partial volume effects.

conclusionThe findings demonstrate that T

Indexed as

Magnetic Iron Oxide NanoparticlesMagnetic Resonance ImagingMagnetite NanoparticlesVisual CortexAnimalsContrast MediaImage EnhancementMaleMiceMice, Inbred C57BLReproducibility of ResultsSensitivity and SpecificityContrast MediaMagnetite Nanoparticlesbright‐blood signalCBV‐fMRIcontrast agentfunctional hyperemiahigh‐resolution fMRInon‐BOLD fMRI

Identifiers

PMID41024509
PMCPMC12681302

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.