ArticleBrain and behavior2025
Ononin, a Natural Isoflavone Glycoside, Alleviates Postoperative Cognitive Dysfunction in Aged Mice by Regulating Neuroinflammation and Oxidative Stress.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Macrophage Migration Inhibitory Factor Inhibitor ISO-1 Attenuates Anesthesia/Surgery-Induced Cognitive Impairment in Aged Mice: Association with NLRP3 Inflammasome Inhibition.Neurochemical research · 2026Article
- Comprehensive Profiling of Chemical Constituents in Niaoduqing Granules by Ultra-High-Performance Liquid Chromatography-Q-Exactive Orbitrap Mass Spectrometry and Identification of Potential Renoprotective Active Components.Journal of separation science · 2026Article
- Ononin-modified Chitosan/β-glycerophosphate hydrogel-loaded adipose-derived stem cells promote the repair of diabetic wounds in rats.BMC biotechnology · 2026Article
- Mechanisms of natural compounds in treating inhalation anesthesia-induced cognitive dysfunction.Frontiers in pharmacology · 2026Review
- Ononin, a Natural Isoflavone Glycoside, Alleviates Postoperative Cognitive Dysfunction in Aged Mice by Regulating Neuroinflammation and Oxidative Stress.Brain and behavior · 2025Article
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8 authors.
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Abstract
objectivePostoperative cognitive dysfunction (POCD) is a serious neurological complication that currently lacks effective clinical prevention and treatment. Ononin, a natural isoflavone glycoside, has been confirmed to exhibit potent neuroprotective effects. This study aimed to investigate whether ononin exerts a neuroprotective role against POCD.
methodsA POCD model was established in 18 months old mice with unilateral nephrectomy. Ononin (30 mg/kg) was administered intraperitoneally 15 min before surgery. On postoperative Day 3, the Morris water maze and open field tests were used to assess cognitive function. The pathological changes and apoptosis of hippocampal neurons were investigated by hematoxylin and eosin (HE) and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. In addition, western blotting and immunofluorescence staining were employed to examine the hippocampal levels of Iba1 and microglial activation. On Days 1 and 3 postsurgery, an enzyme-linked immunosorbent assay (ELISA) was applied to gauge the expression of hippocampal IL-1β, IL-6, and TNF-α. Meanwhile, the levels of hippocampal malondialdehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD) were detected using the corresponding assay kits.
resultsWe found that anesthesia/surgery induced overt spatial memory deficits and neuronal damage in aged mice. Conversely, ononin pretreatment significantly rescued the pathological process and cognitive impairment. Mechanically, anesthesia/surgery triggered acute increases in hippocampal IL-1β, IL-6, TNF-α, Iba1, and MDA, paralleled by a decline in SOD and GSH levels that was partially reversed by ononin.
conclusionsOur findings provide evidence that ononin may ameliorate anesthesia/surgery-induced cognitive deficits through its anti-inflammatory and antioxidant effects, which could be a novel preventive strategy for POCD.
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