ArticleAngewandte Chemie (International ed. in English)2025
Hybrid of Indolizine and Merocyanine-A New Class of Organelle-Specific Dyes.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Hybrid of Indolizine and Merocyanine-A New Class of Organelle-Specific Dyes.Angewandte Chemie (International ed. in English) · 2025Article
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10 authors.
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Abstract
Unlocking the potential of electron-rich 2-hydroxyindolizines led to the discovery of a new class of dyes-indolizine-merocyanines (IndMer) and indolizine-cyanines. Tandem Friedel-Crafts alkylation followed by intramolecular nucleophilic aromatic substitution afforded structurally diverse dyes, as both the nucleophilic and electrophilic partners can be broadly modified. A convergent fragment coupling strategy allowed rapid access to these π-conjugated merocyanines in three steps from pyridines. Uniform distribution of the HOMO and LUMO combined with negligible change of dipole moment upon excitation is responsible for the intense orange or red emission of this new family of reasonably photostable dyes in a broad range of solvents. The new merocyanine dyes have the potential to target a variety of organelles-both uncharged and positively charged indolizine-merocyanines localize a subset of cellular lysosomes, positively charged indolizine-cyanine hybrid accumulates in mitochondria, while coumarin-merocyanine shows context-dependent localization to mitochondria and RNA-rich nucleoli of the living cells.
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