Evidence map›Paper›PMID 41024449›Full record

ArticleObesity (Silver Spring, Md.)2025

Genetic Determinants of Fatty Acid Composition in Subcutaneous and Visceral Adipose Tissue.

Altayeb Ahmed, Afreen Naz, Marjola Thanaj, Elena P Sorokin, Brandon Whitcher, Jimmy D Bell, E Louise Thomas, Madeleine Cule, Hanieh Yaghootkar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Altayeb AhmedSchool of Natural Sciences, College of Health and Science, University of Lincoln, Joseph Banks Laboratories, Lincoln, UK.ORCID https://orcid.org/0000-0003-4748-1991
Afreen NazSchool of Natural Sciences, College of Health and Science, University of Lincoln, Joseph Banks Laboratories, Lincoln, UK.ORCID https://orcid.org/0000-0002-8218-5584
Marjola ThanajResearch Centre for Optimal Health, School of Life Sciences, University of Westminster, London, UK.ORCID https://orcid.org/0000-0002-1789-7112
Elena P SorokinCalico Life Sciences LLC, South San Francisco, California, USA.
Brandon WhitcherResearch Centre for Optimal Health, School of Life Sciences, University of Westminster, London, UK.
Jimmy D BellResearch Centre for Optimal Health, School of Life Sciences, University of Westminster, London, UK.
E Louise ThomasResearch Centre for Optimal Health, School of Life Sciences, University of Westminster, London, UK.ORCID https://orcid.org/0000-0003-4235-4694
Madeleine CuleCalico Life Sciences LLC, South San Francisco, California, USA.
Hanieh YaghootkarSchool of Natural Sciences, College of Health and Science, University of Lincoln, Joseph Banks Laboratories, Lincoln, UK.

Funding

Calico Life Sciences LLCDiabetes UK 23/0006598
6 · The paper itself

Abstract

objectiveFatty acids in adipose tissue are key structural and metabolic regulators of cardiometabolic health, but the genetic architecture governing depot-specific composition in subcutaneous (SAT) and visceral adipose tissue (VAT) is not well defined.

methodsWe used MRI-derived estimates of fatty acid composition in SAT and VAT from 33,583 UK Biobank participants to perform genome-wide association studies. Functional annotation, fine mapping, colocalization, and expression QTL analyses were conducted to prioritize likely causal variants and explore mechanisms.

resultsWe identified six loci associated with adipose tissue fatty acid composition, including both shared (PKD2L1, INSIG1) and depot-specific associations (LEKR1 and KLF14 for SAT; CDCA2 for VAT). The strongest association, rs603424-G (near PKD2L1), was linked to higher monounsaturated and polyunsaturated fatty acids, lower saturated fatty acids, and increased SCD1 expression in SAT and VAT, suggesting a role in desaturation and lipid remodeling. Several loci were linked to cardiometabolic outcomes including type 2 diabetes, hypertension, and cholelithiasis, with functional evidence supporting gene-diet interactions at the PKD2L1 locus.

conclusionsOur findings uncover genetic determinants of human adipose tissue fatty acid composition, highlight depot-specific regulation, and point to SCD1 as a potential metabolic regulator. These results deepen understanding of lipid metabolism and its links to cardiometabolic risk.

Indexed as

Fatty AcidsIntra-Abdominal FatSubcutaneous FatAdultAgedDiabetes Mellitus, Type 2FemaleGenome-Wide Association StudyHumansKruppel-Like Transcription FactorsMagnetic Resonance ImagingMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociFatty AcidsKLF14 protein, humanKruppel-Like Transcription Factorscardiometabolic diseasefatty acidsMRI scanSCD1visceral adipose tissue

Identifiers

PMID41024449
PMCPMC12636063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.