Evidence map›Paper›PMID 41024355›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Structure-Tailoring Cerium Nanozymes with Self-Cascade ROS Scavenging Catalysis Modulate the Microbiota-Gut-Joint Axis for Rheumatoid Arthritis Therapy.

Ge Wang, Xueqing Zhang, Boyuan Zhu, Suyue Ding, Dong Yan, Jing Ma, Yafang Xiao, Yafu Wang, Tianjun Ni, Hua Zhang and 1 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ge WangSchool of Basic Medical Sciences, Xinxiang Medical University, School of Pharmacy, Xinxiang Medical University, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453007, P. R. China.
Xueqing ZhangSchool of Basic Medical Sciences, Xinxiang Medical University, School of Pharmacy, Xinxiang Medical University, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453007, P. R. China.
Boyuan ZhuSchool of Basic Medical Sciences, Xinxiang Medical University, School of Pharmacy, Xinxiang Medical University, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453007, P. R. China.
Suyue DingSchool of Basic Medical Sciences, Xinxiang Medical University, School of Pharmacy, Xinxiang Medical University, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453007, P. R. China.
Dong YanSchool of Basic Medical Sciences, Xinxiang Medical University, School of Pharmacy, Xinxiang Medical University, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453007, P. R. China.
Jing MaDepartment of Minimally Invasive Interventional Radiology, The Second Affiliated Hospital, School of Biomedical Engineering Guangzhou Medical University, Guangzhou, 510260, P. R. China.
Yafang XiaoDepartment of Minimally Invasive Interventional Radiology, The Second Affiliated Hospital, School of Biomedical Engineering Guangzhou Medical University, Guangzhou, 510260, P. R. China.
Yafu WangKey Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, 453007, P. R. China.
Tianjun NiSchool of Basic Medical Sciences, Xinxiang Medical University, School of Pharmacy, Xinxiang Medical University, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453007, P. R. China.
Hua ZhangKey Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, 453007, P. R. China.
Weisheng GuoDepartment of Minimally Invasive Interventional Radiology, The Second Affiliated Hospital, School of Biomedical Engineering Guangzhou Medical University, Guangzhou, 510260, P. R. China.ORCID https://orcid.org/0000-0002-8064-357X

Funding

Basic Research Special Project of Key Research Projects in Higher Education Institutions in Henan Province 24ZX009National Natural Science Foundation of China 22107089National Natural Science Foundation of China 52271251National Natural Science Foundation of China U21A20314Natural Science Foundation of Henan 242300421210Program for Innovative Research Team (in Science and Technology) in University of Henan Province 23IRTSTHN002
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is closely associated with intestinal microbiota dysbiosis, highlighting the therapeutic potential of targeting the microbiota-gut-joint axis. Current interventions often overlook the cascade nature of reactive oxygen species (ROS) generation in driving intestinal and systemic inflammation. Herein, a valence-engineered CeO

Indexed as

Arthritis, RheumatoidCeriumGastrointestinal MicrobiomeReactive Oxygen SpeciesAnimalsCatalysisDisease Models, AnimalMaleRatsRats, Sprague-DawleyCeriumReactive Oxygen Speciescerium nanozymesgut‐joint axisrheumatoid arthritisself‐cascade

Identifiers

PMID41024355
PMCPMC12713043

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.