Evidence map›Paper›PMID 41024272›Full record

ArticleTrials2025

Resilience And Healthy Lifestyle for Rheumatoid Arthritis (The RA-HEAL trial): a randomised, parallel group, placebo-controlled clinical trial protocol.

Katherine A Poulsen, Nicola W Burton, Hannah L Mayr, Veronique S Chachay, Jeff S Coombes, Coral E Gartner, Amee Sonigra, Paul Christensen, Karl A Hansford, Dianna J Ang and 10 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Katherine A PoulsenFrazer Institute, The University of Queensland, Wolloongabba, QLD, 4102, Australia.
Nicola W BurtonSchool of Applied Psychology, Griffith University, Brisbane, QLD, 4111, Australia.
Hannah L MayrDepartment of Nutrition and Dietetics, Princess Alexandra Hospital, Brisbane, QLD, 4102, Australia.
Veronique S ChachayFrazer Institute, The University of Queensland, Wolloongabba, QLD, 4102, Australia.
Jeff S CoombesSchool of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia.
Coral E GartnerFrazer Institute, The University of Queensland, Wolloongabba, QLD, 4102, Australia.
Amee SonigraDepartment of Rheumatology, Princess Alexandra Hospital, Brisbane, QLD, 4102, Australia.
Paul ChristensenFrazer Institute, The University of Queensland, Wolloongabba, QLD, 4102, Australia.
Karl A HansfordFrazer Institute, The University of Queensland, Wolloongabba, QLD, 4102, Australia.
Dianna J AngFrazer Institute, The University of Queensland, Wolloongabba, QLD, 4102, Australia.
Jessica NeriThe Arthritis Movement, PO Box 2121, Lutwyche, QLD, 4030, Australia.
Ramali MendisDepartment of Rheumatology, Princess Alexandra Hospital, Brisbane, QLD, 4102, Australia.
Tom LynchInstitute of Bone and Joint Research, The Australian Arthritis and Autoimmune Biobank Collaborative, Kolling Institute, The University of Sydney, St Leonards, NSW, 2065, Australia.
Cheryl DinesThe Arthritis Movement, PO Box 2121, Lutwyche, QLD, 4030, Australia.
Helen BenhamInstitute of Bone and Joint Research, The Australian Arthritis and Autoimmune Biobank Collaborative, Kolling Institute, The University of Sydney, St Leonards, NSW, 2065, Australia.
Aoife SweeneyFrazer Institute, The University of Queensland, Wolloongabba, QLD, 4102, Australia.
Lyn M MarchInstitute of Bone and Joint Research, The Australian Arthritis and Autoimmune Biobank Collaborative, Kolling Institute, The University of Sydney, St Leonards, NSW, 2065, Australia.
Asaduzzaman KhanSchool of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia.
Haitham TuffahaCentre for the Business and Economics of Health, The University of Queensland, Brisbane, QLD, 4072, Australia.
Ranjeny ThomasFrazer Institute, The University of Queensland, Wolloongabba, QLD, 4102, Australia. ranjeny.thomas@uq.edu.au.ORCID http://orcid.org/0000-0002-0518-8386

Funding

MRFF 2032246
6 · The paper itself

Abstract

backgroundThe importance of self-management strategies that optimise physical health and mental health in the management of rheumatoid arthritis (RA) is recognised, but access to multidisciplinary teams to support this can be challenging. Furthermore, evidence for the impact of multidisciplinary interventions, especially in early RA, is lacking.

methodsThe Resilience and Healthy Lifestyle for Rheumatoid Arthritis (RA-HEAL) Trial is a pragmatic RCT that aims to compare the effects of a structured multidisciplinary lifestyle intervention with self-directed activities in best-practice usual care. The 20-week multi-modal intervention incorporates structured resilience training conducted by a clinical health psychologist (CHP), followed by an exercise physiologist (EP)-led exercise programme, dietary education conducted by a dietitian nutritionist (DN), a smoking cessation programme (where applicable) and psychologist-led behaviour-change support. The comparison group will receive written information on a healthy lifestyle in accordance with standard best practice care. The primary outcome is health-related quality of life (QoL) at 6 months. DISCUSSION: RA-HEAL tests whether a tailored intervention including formal resilience training with a clinical psychologist followed by Mediterranean diet, exercise, smoking cessation and behaviour change support has a greater effect on health-related QoL at 6 months than written advice given in current best-practice settings. QoL is a composite endpoint that is highly valued by patients with RA. RA-HEAL is unique in that it targets RA within 12 months of onset. RA-HEAL's linkage with the Australian Autoimmune Arthritis Biobank Cooperative (A3BC) supports 6 monthly follow-up data and biosampling to 24 months post-intervention and linkage to health data collections, creating a valuable resource for future research and the potential to determine medium and long-term effects of behaviour change. In its secondary outcomes, RA-HEAL will analyse the longevity of effects of intervention or best-practice usual care for up to 2 years and cost utility. The outcomes should provide evidence to underpin a scalable approach to support people with newly diagnosed RA.

trial registrationACTRN12625000050459, ANZCTR. Registered on 20 January 2025.

Indexed as

Arthritis, RheumatoidHealthy LifestyleResilience, PsychologicalDiet, MediterraneanExercise TherapyHumansPragmatic Clinical Trials as TopicQuality of LifeSmoking CessationTreatment OutcomeBehavior changeBiosamplesDietExerciseLifestyle interventionQuality-of-lifeResilience trainingRheumatoid arthritis

Identifiers

PMID41024272
PMCPMC12482164

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.