Evidence map›Paper›PMID 41024247›Full record

ArticleJournal of medical case reports2025

Metaplastic carcinoma of breast with heterologous mesenchymal differentiation (carcinosarcoma) having an endothelial component: a case report.

Shubham Dokania, Lincoln Pujari, Prashanth Giridhar, Abhishek Shinghal, Ankita Rungta Kapoor, Avradeep Datta, Zachariah Chowdhury, Anuj Gupta, Mayank Tripathi, Pritam Mondal and 1 more

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Article in Journal of medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Shubham DokaniaDepartment of Radiation Oncology, Homi Bhabha Cancer Hospital, Homi Bhabha National University, Varanasi, Uttar Pradesh, India.
Lincoln PujariDepartment of Radiation Oncology, Homi Bhabha Cancer Hospital, Homi Bhabha National University, Varanasi, Uttar Pradesh, India.
Prashanth GiridharDepartment of Radiation Oncology, Homi Bhabha Cancer Hospital, Homi Bhabha National University, Varanasi, Uttar Pradesh, India.
Abhishek ShinghalDepartment of Radiation Oncology, Homi Bhabha Cancer Hospital, Homi Bhabha National University, Varanasi, Uttar Pradesh, India.
Ankita Rungta KapoorDepartment of Radiation Oncology, Homi Bhabha Cancer Hospital, Homi Bhabha National University, Varanasi, Uttar Pradesh, India.
Avradeep DattaDepartment of Radiation Oncology, Homi Bhabha Cancer Hospital, Homi Bhabha National University, Varanasi, Uttar Pradesh, India.
Zachariah ChowdhuryDepartment of Oncopathology, Homi Bhabha Cancer Hospital, Homi Bhabha National University, Varanasi, Uttar Pradesh, India.
Anuj GuptaDepartment of Medical Oncology, Homi Bhabha Cancer Hospital, Homi Bhabha National University, Varanasi, Uttar Pradesh, India.
Mayank TripathiDepartment of Surgical Oncology, Homi Bhabha Cancer Hospital Cancer Centre, Homi Bhabha National University, Varanasi, Uttar Pradesh, India.
Pritam MondalDepartment of Radiation Oncology, Homi Bhabha Cancer Hospital, Homi Bhabha National University, Varanasi, Uttar Pradesh, India.
Satyajit PradhanDepartment of Radiation Oncology, Homi Bhabha Cancer Hospital, Homi Bhabha National University, Varanasi, Uttar Pradesh, India. satyajitpradhan1961@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetaplastic breast cancer with heterologous mesenchymal differentiation, known earlier as carcinosarcoma, consists of both infiltrating ductal carcinoma cells and mesenchymal cells, and is associated with an aggressive course. The mesenchymal component is rarely endothelial, with only two previously reported cases. The present case is the third among those. Moreover, the disease outcome was good, unlike the usual course of carcinosarcoma. CASE PRESENTATION: A 59-year-old multiparous woman of Indo-aryan ethnicity developed a lump in her left breast and was diagnosed with breast carcinosarcoma having an endothelial component, with the help of histopathological examination and immunohistochemistry. The tumor was surgically removed; then the patient received adjuvant chemotherapy, epirubicin, and cyclophosphamide, followed by adjuvant radiotherapy to the whole breast, followed by tumor bed boost. The patient was clinic-radiologically disease-free even at 26 months post-treatment.

conclusionSurgery followed by adjuvant chemotherapy and radiotherapy gives better outcomes compared with surgery alone, with a doubtful role of neoadjuvant chemotherapy. Targeted therapies can be considered in patients not responding to conventional treatment.

Indexed as

Breast NeoplasmsCarcinosarcomaChemotherapy, AdjuvantEpirubicinFemaleHumansMetaplasiaMiddle AgedRadiotherapy, AdjuvantTreatment OutcomeEpirubicinCarcinosarcomaCase reportEndothelial componentImmunohistochemistryMetaplastic breast cancer

Identifiers

PMID41024247
PMCPMC12482789

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