ArticleJournal of orthopaedic surgery and research2025
KDM6B promotes ferroptosis in rheumatoid arthritis fibroblast-like synoviocytes via the miR-128-3p/SLC7A11 axis through H3K27me3 modification.
Article in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Exploring the Association Between Rheumatoid Arthritis and Parkinson's Disease: Evidence from 2001-2016 NHANES, Real-World Clinical Data and Bioinformatics Analysis.Journal of inflammation research · 2026Article
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5 authors.
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Abstract
backgroundRheumatoid arthritis (RA) is a chronic inflammatory joint disease, primarily driven by fibroblast-like synoviocytes (FLSs) that trigger synovial inflammation and joint destruction. This study explores the mechanisms of KDM6B in ferroptosis in RA-FLSs, providing a theoretical basis for the treatment of RA.
methodsRA-FLSs were isolated from RA synovial tissue samples. si-KDM6B was transfected into RA-FLSs, followed by the detection of KDM6B and miR-128-3p using qRT-PCR and Western blot. Cell viability was assessed using the CCK-8 assay. The levels of ROS, GSH, MDA, and Fe
resultsKDM6B was highly expressed in RA tissues and RA-FLSs. Inhibition of KDM6B increased cell viability, elevated ROS, MDA, and Fe
conclusionKDM6B promotes ferroptosis in RA-FLSs via the miR-128-3p/SLC7A11 axis through the removal of histone H3K27me3 modification.
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