Evidence map›Paper›PMID 41024200›Full record

ReviewBioelectronic medicine2025

Efficacy and mechanisms of neuromodulation in the treatment of irritable bowel syndrome.

Kaijie Wang, Md Jahangir Alam, Xinya Lan, Fei Li, Jiande D Z Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioelectronic medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kaijie Wang *Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, 1150 E Medical Center Dr, Ann Arbor, MI, 48109, USA.
Md Jahangir Alam *Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, 1150 E Medical Center Dr, Ann Arbor, MI, 48109, USA.
Xinya LanRehabilitation Medicine Center, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.
Fei LiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, 1150 E Medical Center Dr, Ann Arbor, MI, 48109, USA.
Jiande D Z ChenDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, 1150 E Medical Center Dr, Ann Arbor, MI, 48109, USA. cjiande@med.umich.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disorders of gut-brain interaction (DGBI), including irritable bowel syndrome (IBS), have a significant impact on patients, reducing their quality of life and work efficiency. Pharmacological therapy is primarily used as a frontline treatment option for treating IBS. However, owing to the heterogeneous characteristics of IBS and its limited pathophysiological understanding, pharmacological therapy is rather disappointing. Therefore, patients with IBS often use alternative therapies, such as electrical neuromodulation, to treat IBS-related symptoms. Neuromodulation includes invasive and noninvasive methods via implanted electrodes and transcutaneous electrodes, respectively. In this manuscript, we reviewed the therapeutic effects of several electrical neuromodulation approaches, including sacral nerve stimulation, spinal cord stimulation, auricular vagal nerve stimulation, and transcutaneous electrical acustimulation, on the symptoms of IBS. Additionally, we discussed the potential mechanisms, adverse effects, advantages, and disadvantages of different neuromodulation treatment methods.

Indexed as

Irritable bowel syndromeNeuromodulationPercutaneous electrical nerve field stimulationSacral nerve stimulationSpinal cord stimulationTranscutaneous auricular vagal nerve stimulationTranscutaneous electrical acustimulation

Identifiers

PMID41024200
PMCPMC12482269

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.