ArticleEuropean journal of medical research2025
Association between mean corpuscular hemoglobin concentration and mortality in ICU patients with acute kidney injury: a retrospective multicenter cohort study.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe prognostic value of mean corpuscular hemoglobin concentration (MCHC) in ICU patients with acute kidney injury (AKI) is unclear.
methodsWe performed a retrospective multicenter cohort study using MIMIC-IV and eICU-CRD. Adults with AKI and an admission MCHC (first 24 h) were included. Outcomes were 30-and 90-day in-hospital mortality. Survival was compared across MCHC quartiles, and Cox models (with restricted cubic splines) estimated adjusted associations.
resultsAmong 111,817 patients (MIMIC-IV n = 54,422; eICU-CRD n = 57,395), higher MCHC was associated with lower mortality. Survival differed across MCHC quartiles (log-rank p < 0.0001 in both cohorts). In adjusted models, the highest vs. lowest MCHC quartile had a lower risk of death (MIMIC-IV HR 0.65, 95% CI 0.60-0.70; eICU-CRD HR 0.62, 95% CI 0.58-0.66). Spline analyses suggested a nonlinear association in MIMIC-IV and an approximately linear association in eICU-CRD.
conclusionsAdmission MCHC was associated with 30-and 90-day mortality in ICU patients with AKI across two large databases. MCHC may aid risk stratification in this population.
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