Evidence map›Paper›PMID 41024124›Full record

ArticleActa neuropathologica communications2025

Telomere-driven senescence accelerates tau pathology, neuroinflammation and neurodegeneration in a tauopathy mouse model.

Debora Palomares, Axelle A T Vanparys, Joana Jorgji, Esther Paître, Pascal Kienlen-Campard, Nuria Suelves

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Debora PalomaresAging and Dementia Group, Cellular and Molecular Division (CEMO), Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium.
Axelle A T VanparysAging and Dementia Group, Cellular and Molecular Division (CEMO), Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium.
Joana JorgjiAging and Dementia Group, Cellular and Molecular Division (CEMO), Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium.
Esther PaîtreAging and Dementia Group, Cellular and Molecular Division (CEMO), Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium.
Pascal Kienlen-CampardAging and Dementia Group, Cellular and Molecular Division (CEMO), Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium. pascal.kienlen-campard@uclouvain.be.
Nuria SuelvesAging and Dementia Group, Cellular and Molecular Division (CEMO), Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium. nuria.suelves@uclouvain.be.

Funding

FRS-FNRS (Fonds National pour la Recherche Scientifique) 40015405/40030154FRS-FNRS (Fonds National pour la Recherche Scientifique) FNRS J.0106.22Queen Elisabeth Medical Foundation FMRE AlzHexSAO-FRA Alzheimer Research Foundation SAO-FRA 2018/0025SAO-FRA Alzheimer Research Foundation SAO-FRA 2020/0028UCLouvain Action de Recherche Concertée ARC21/26-114
6 · The paper itself

Abstract

The connection between aging and neurodegenerative pathologies like Alzheimer's disease (AD) has long been recognized, with senescent brain cells building up in the brains of AD patients. A causal link has been established between senescence and AD-related tauopathy, but the mechanisms underlying these pathological changes remain largely unknown. To unravel the precise role of cellular senescence in tau-mediated neuropathology, we crossed the Terc knockout (Terc

Indexed as

AgingBrainCellular SenescenceNerve DegenerationNeuroinflammatory DiseasesTauopathiestau ProteinsTelomereAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutMice, Transgenictau ProteinsAlzheimer’s diseaseCellular senescenceNeurodegenerationNeuroinflammationTau pathologyTelomere shortening

Identifiers

PMID41024124
PMCPMC12482832

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.