Evidence map›Paper›PMID 41024114›Full record

Trial reportCritical care (London, England)2025

Comparison of two transpulmonary pressure-based positive end-expiratory pressure titration strategies in acute respiratory distress syndrome: a randomized crossover study.

Dara Chean, Antonin Courtais, Bertrand Pavlovsky, Elise Yvin, Christophe Desprez, Mathilde Taillantou-Candau, Lise Piquilloud, Jean-Christophe Richard, Alain Mercat, François M Beloncle

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03281473 (Comparison of Positive End Expiratory Pressure Titration Methods in Patients With Acute Respiratory Distress Syndrome), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03281473 naunknown statusnot on this map

Comparison of Positive End Expiratory Pressure Titration Methods in Patients With Acute Respiratory Distress Syndrome: a Physiological Study

TypeinterventionalSponsorUniversity Hospital, AngersRan2018 to 2019Enrolled20ConditionsAcute Respiratory Distress SyndromeArmsStrategy 1, Strategy 2
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dara CheanMedical ICU, University Hospital of Angers, Vent'Lab, University of Angers, 4 rue Larrey, F-49933 Angers Cedex 9, Angers, France.
Antonin CourtaisMedical ICU, University Hospital of Angers, Vent'Lab, University of Angers, 4 rue Larrey, F-49933 Angers Cedex 9, Angers, France.
Bertrand PavlovskyMedical ICU, University Hospital of Angers, Vent'Lab, University of Angers, 4 rue Larrey, F-49933 Angers Cedex 9, Angers, France.
Elise YvinMedical ICU, University Hospital of Angers, Vent'Lab, University of Angers, 4 rue Larrey, F-49933 Angers Cedex 9, Angers, France.
Christophe DesprezMedical ICU, University Hospital of Angers, Vent'Lab, University of Angers, 4 rue Larrey, F-49933 Angers Cedex 9, Angers, France.
Mathilde Taillantou-CandauMedical ICU, University Hospital of Angers, Vent'Lab, University of Angers, 4 rue Larrey, F-49933 Angers Cedex 9, Angers, France.
Lise PiquilloudAdult Intensive Care Unit, University Hospital and University of Lausanne, Lausanne, Switzerland.
Jean-Christophe RichardMedical ICU, University Hospital of Angers, Vent'Lab, University of Angers, 4 rue Larrey, F-49933 Angers Cedex 9, Angers, France.
Alain MercatMedical ICU, University Hospital of Angers, Vent'Lab, University of Angers, 4 rue Larrey, F-49933 Angers Cedex 9, Angers, France.
François M BeloncleMedical ICU, University Hospital of Angers, Vent'Lab, University of Angers, 4 rue Larrey, F-49933 Angers Cedex 9, Angers, France. francois.beloncle@univ-angers.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEsophageal pressure monitoring, which enables the estimation of transpulmonary pressure, has been proposed to personalize ventilator settings, particularly positive end-expiratory pressure (PEEP), in patients with acute respiratory distress syndrome (ARDS). Two conceptually different transpulmonary pressure-based PEEP titration strategies have thus been described but have never been compared. This study aims to compare the PEEP levels obtained with these two distinct strategies and their physiological effects.

methodsThis was a randomized crossover physiological study. Twenty patients with moderate to severe ARDS (PaO

resultsMedian PEEP levels determined by the two strategies were not different; however, individual values were uncorrelated, with a difference of at least 3 cmH

conclusionsThe two transpulmonary pressure-based titration strategies result in different PEEP levels in most patients. Neither strategy is associated with higher recruited lung volume or lower estimated Stress and Strain.

trial registration#NCT03281473 Clinicaltrials.gov. Registered 12 September 2017.

Indexed as

Positive-Pressure RespirationRespiratory Distress SyndromeAdultAgedCross-Over StudiesFemaleHumansMaleMiddle AgedARDSChest wallEsophageal pressureLung recruitmentMechanical ventilationObesityPositive end-expiratory pressureRespiratory mechanics

Identifiers

PMID41024114
PMCPMC12481819

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.