Evidence map›Paper›PMID 41024109›Full record

ArticleTrials2025

The utility of pericapsular nerve group (PENG) block versus intrathecal morphine for postoperative analgesia in anterior approach total hip arthroplasty: a multicentre triple blinded randomised controlled trial protocol.

Craig Morrison, Tim Cheok, Brigid Brown, Bronwyn Lock, Gemma Saville, Louise de Prinse, Holly Alford, Marni Calvert, Dimitrios Nikos, Nikki May and 4 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Craig MorrisonCollege of Medicine and Public Health, Flinders University, Bedford Park, Adelaide, SA, Australia. craig.morrison@sa.gov.au.ORCID http://orcid.org/0000-0001-9200-2430
Tim CheokCollege of Medicine and Public Health, Flinders University, Bedford Park, Adelaide, SA, Australia.
Brigid BrownCollege of Medicine and Public Health, Flinders University, Bedford Park, Adelaide, SA, Australia.
Bronwyn LockDepartment of Anesthesiology, Flinders Medical Centre, Bedford Park, Adelaide, SA, Australia.
Gemma SavilleDepartment of Anesthesiology, Flinders Medical Centre, Bedford Park, Adelaide, SA, Australia.
Louise de PrinseDepartment of Anesthesiology, Flinders Medical Centre, Bedford Park, Adelaide, SA, Australia.
Holly AlfordDepartment of Anesthesiology, Flinders Medical Centre, Bedford Park, Adelaide, SA, Australia.
Marni CalvertCollege of Medicine and Public Health, Flinders University, Bedford Park, Adelaide, SA, Australia.
Dimitrios NikosDepartment of Orthopaedic Surgery, Flinders Medical Centre, Bedford Park, Adelaide, SA, Australia.
Nikki MayGus Fraenkel Medical Library, Flinders University, Bedford Park, Adelaide, SA, Australia.
Hidde M KroonDepartment of Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Ruurd JaarsmaCollege of Medicine and Public Health, Flinders University, Bedford Park, Adelaide, SA, Australia.
Ki Jinn ChinDepartment of Anesthesiology and Pain Medicine, Toronto Western Hospital, University of Toronto, Toronto, Canada.
D-Yin LinCollege of Medicine and Public Health, Flinders University, Bedford Park, Adelaide, SA, Australia.

Funding

Australian Society of Anaesthetists Jackson Rees Research Grant
6 · The paper itself

Abstract

backgroundThe pericapsular nerve group (PENG) block is a novel regional technique for hip analgesia. Traditionally, intrathecal morphine has been administered for analgesia in hip fracture surgery. Compared with intrathecal morphine, the PENG block may provide superior or equivalent pain score reduction with a more favourable side effect profile and superior patient satisfaction.

methodsThis is a multicentre blinded randomised controlled trial (RCT) that is being conducted at present at two large teaching institutions in Australia. The pericapsular nerve group block (PENG block) shall be compared to low-dose intrathecal morphine for analgesic effect in elective total Hip arthroplasty via the direct anterior approach. Primary outcome shall be dynamic pain score evaluation at 3 and 24 h postoperatively. DISCUSSION: This is the protocol of our RCT which is currently in the early stages of active recruitment.

trial registrationEthics approval was obtained from the Southern Area Local Health Network prior to recruitment of the first patient. This trial was prospectively registered prior to initiation on the Australian and New Zealand Clinical Trials Registry. Australian New Zealand Clinical Trial Registry, ACTRN12623001309673P, 15/12/23, https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=386688&showOriginal=true&isReview=true .

Indexed as

Analgesics, OpioidArthroplasty, Replacement, HipMorphineNerve BlockPostoperative PainAustraliaHumansInjections, SpinalMulticenter Studies as TopicPain MeasurementProspective StudiesRandomized Controlled Trials as TopicResearch DesignTime FactorsTreatment OutcomeAnalgesics, OpioidMorphineAnalgesiaIntrathecal morphinePENG blockPericapsular nerve group blockRegional anaesthesiaTotal hip arthroplastyTotal hip replacement

Identifiers

PMID41024109
PMCPMC12482444

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.