ArticleBMC women's health2025
Diet, oxidative stress, and the mediating role of obesity in postmenopausal women.
Article in BMC women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The association of the composite dietary antioxidant index with the risk of cardiometabolic disorders: findings from the Tehran Lipid and Glucose Study.Journal of health, population, and nutrition · 2026Article
- Effect of Normal Level Endocrine Hormones and Hypothalamic Neuropeptides on Obesity in Women of Childbearing Age.Journal of obesity · 2026Article
- Acute Impact of Polyphenol-Rich vs. Carbohydrate-Rich Foods and Beverages on Exercise-Induced ROS and FRAP in Healthy Sedentary Female Adults-A Randomized Controlled Trial.Antioxidants (Basel, Switzerland) · 2025Article
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4 authors.
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Abstract
backgroundOxidative stress plays a critical role in age-related pathophysiology, and postmenopausal women are particularly vulnerable due to hormonal and metabolic changes. Although dietary quality has been implicated in modulating oxidative balance, few studies have explored whether obesity mediates this relationship in this population, representing a novel perspective in dietary-oxidative research.
objectivesThis study aimed to examine the associations between dietary quality and oxidative stress among postmenopausal women using data from the National Health and Nutrition Examination Survey (NHANES), and to assess whether obesity mediates this relationship.
methodsA total of 2,391 postmenopausal women from NHANES 2005–2020 were included. Dietary quality was assessed using the Healthy Eating Index (HEI-2015), Dietary Inflammatory Index (DII), and Composite Dietary Antioxidant Index (CDAI). Oxidative stress was measured using the Oxidative Balance Score (OBS), and obesity was evaluated by body mass index and waist circumference. Multivariable regression and mediation analysis were conducted to explore the relationships.
resultsHealthier diets (higher HEI and CDAI, lower DII) were significantly associated with better oxidative profiles and lower obesity indicators. Obesity was inversely associated with oxidative stress. Mediation analysis showed that obesity partially explained the association between diet and oxidative stress, indicating an indirect pathway linking dietary quality to oxidative status via adiposity.
conclusionsOur findings reveal a significant mediating role of obesity in the relationship between diet and oxidative stress in postmenopausal women. These results underscore the importance of integrated dietary and weight management strategies—such as promoting antioxidant-rich diets and obesity prevention—in mitigating oxidative stress-related health risks in this population.
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