ArticleGut pathogens2025
Helicobacter pylori infection is associated with an increased risk of chronic obstructive pulmonary disease and asthma.
Article in Gut pathogens, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The association between Helicobacter pylori infection and asthma risk: an updated systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundHelicobacter pylori infection, commonly observed in peptic ulcers, induces chronic systemic inflammation. Chronic obstructive pulmonary disease (COPD) and asthma are inflammatory airway diseases. We investigated the association of H. pylori infection with COPD and asthma.
methodsData from individuals who underwent H. pylori eradication treatment between 2009 and 2017 were obtained from the Korean National Health Insurance Database. In total, 33,017 individuals aged ≥ 40 years with H. pylori infection and 168,524 matched controls were identified and monitored until December 2019. Multivariate Cox proportional hazards models were used to estimate the adjusted hazard ratios (aHR) for risk factors associated with COPD and asthma.
resultsThe incidences of COPD and asthma among individuals with H. pylori infection were 10.92/1,000 person-years and 15.99/1,000 person-years, respectively. The risk of developing COPD (aHR 1.13, 95% confidence interval [CI] 1.08-1.19) and asthma (aHR 1.17, 95% CI 1.12-1.22) was higher among individuals with H. pylori infection, even after adjusting for smoking status. Subgroup analysis revealed that the risk of COPD was more pronounced among older adults (≥ 65 years) and current smokers. In contrast, the risk for asthma did not differ according to age or smoking status.
conclusionsH. pylori infection is associated with an increased risk of COPD and asthma. The risk of asthma was consistent across age groups and smoking statuses; in contrast, the risk of COPD varied. The findings of the present study underscore the pathophysiological interactions between chronic inflammation in the stomach and the lungs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.