Evidence map›Paper›PMID 41024076›Full record

ArticleJournal of nanobiotechnology2025

Aligned nanofiber-based responsive sponge scaffolds for peripheral nerve regeneration.

Sizhe Song, Ying Zhang, Dongyu Xu, Hui Zhang, Yu Wang, Huan Wang, Hao Wu, Renjie Chai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sizhe SongState Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China.
Ying ZhangDepartment of Neurology, Aerospace Center Hospital, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Dongyu XuState Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China.
Hui ZhangState Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China.
Yu WangWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China. yuwang@wiucas.ac.cn.
Huan WangThe Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, China. wangh679@mail.sysu.edu.cn.
Hao WuDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100081, China. wuhaospine@xwh.ccmu.edu.cn.
Renjie ChaiState Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China. renjiec@seu.edu.cn.

Funding

Guangdong Basic and Applied Basic Research Foundation 2023A1515011986Jiangsu Provincial Scientific Research Center of Applied Mathematics BK20233002National Key Research and Development Program of China 2021YFA1101300National Natural Science Foundation of China 22302231National Natural Science Foundation of China 52403189National Natural Science Foundation of China 82330033Natural Science Foundation of Jiangsu Province BK20220170Natural Science Foundation of Jiangsu Province BK20232007Open Project Fund of Guangdong Academy of Medical Sciences YKY-KF202201Science and Technology Department of Sichuan Province 2021YFS0371SEU Innovation Capability Enhancement Plan for Doctoral Students CHJH_SEU 25033Shenzhen Fundamental Research Program JCYJ20210324125608022Shenzhen Medical Research Fund B2401007Shenzhen Medical Research Fund (B2401007), Futian Healthcare Research Project FTWS2022013Wenzhou Institute UCAS startup fund WIUCASQD2024009
6 · The paper itself

Abstract

Nerve conduits have demonstrated tremendous value in advancing nerve regeneration. The current research focuses on improving their neuro regenerative effects through structural optimization and functional enhancement. Here, an original responsive sponge nerve conduit (RSNC) comprising a three-dimensional (3D) foamed nanofiber scaffold integrated with polydopamine-coated black phosphorus (PDA@BP) hydrogel is developed to promote sciatic nerve regeneration. The aligned nanofibrous mats are prepared by electrospinning and then foamed by gas foaming technology to obtain 3D sponge nanofiber scaffolds, which are subsequently filled with conductive PDA@BP doped gelatin methacryloyl hydrogels. Leveraging the superior photothermal conversion efficiency of PDA@BP nanosheets, loaded nerve growth factors are released under near-infrared light exposure, thereby promoting cell differentiation. In vivo experiments notably prove that RSNCs excel in facilitating nerve regeneration and motor function recovery, highlighting their potential for clinical peripheral nerve repair and related biomedical applications.

Indexed as

NanofibersNerve RegenerationTissue ScaffoldsAnimalsCell DifferentiationHydrogelsIndolesMaleMicePolymersRatsRats, Sprague-DawleySciatic NerveTissue EngineeringHydrogelsIndolespolydopaminePolymersBlack phosphorusConductivityNanofiber scaffoldsNerve regenerationPhotothermal responsiveness

Identifiers

PMID41024076
PMCPMC12481970

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.