Evidence map›Paper›PMID 41024055›Full record

ArticleBMC oral health2025

Effect of scaling and root planing on TNF-α, IL-1β, and IL-10 levels in periodontitis patients with and without diabetes: a cross-sectional study.

Guangna Yue, Jing Qian, Beimiao Weng, Jingyan Mao, Min Zhang, Shaohai Wang, Weiqin Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guangna Yue *Department of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Jing Qian *Department of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Beimiao WengDepartment of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Jingyan MaoDepartment of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Min ZhangShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Implantology, Stomatological Hospital, Dental School, Tongji University, Shanghai, China.
Shaohai WangDepartment of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China. shaohaiwang@tongji.edu.cn.
Weiqin HuangDepartment of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China. hwq13621894651@163.com.

Funding

Key Specialty Construction Project of Shanghai Pudong New Area Health Commission PWZzb2022-17
6 · The paper itself

Abstract

objectiveTo evaluate the effect of scaling and root planing (SRP) on clinical periodontal parameters and gingival crevicular fluid (GCF) levels of TNF-α, IL-1β, and IL-10 in periodontitis patients with and without diabetes.

methodsA cross-sectional study was conducted involving 76 patients diagnosed with periodontitis, including 38 with diabetes and 38 without diabetes. All participants received standardized SRP treatment. Periodontal clinical parameters and glycated hemoglobin (HbA1c) levels (in diabetic patients) were recorded at baseline and three months post-treatment. GCF samples were collected to assess concentrations of TNF-α, IL-1β, and IL-10 using ELISA. Changes in inflammatory cytokine levels were compared between the two groups before and after treatment.

resultsSRP led to significant improvements in probing depth (PD), clinical attachment loss (CAL), bleeding index (BI), and plaque index (PLI) in both groups, with no significant intergroup differences. Diabetic patients showed a mean HbA1c reduction of 0.30 ± 1.24%. TNF-α levels significantly decreased in both groups post-treatment (P < 0.001); however, post-treatment TNF-α levels remained significantly higher in the diabetes group than in the non-diabetes group (P < 0.001). No significant changes were observed in IL-1β levels in either group. IL-10 levels increased more in the non-diabetic group than in the diabetic group, though the difference was not statistically significant (P = 0.422).

conclusionSRP treatment effectively improves periodontal clinical outcomes and modulates local inflammatory mediator levels. These findings highlight the need for individualized treatment strategies and interdisciplinary management in diabetic patients with periodontitis.

Indexed as

Dental ScalingInterleukin-10Interleukin-1betaPeriodontitisRoot PlaningTumor Necrosis Factor-alphaAdultCross-Sectional StudiesDental Plaque IndexFemaleGingival Crevicular FluidGlycated HemoglobinHumansMaleMiddle AgedPeriodontal IndexGlycated HemoglobinIL10 protein, humanInterleukin-10Interleukin-1betaTumor Necrosis Factor-alphaDiabetesIL-10IL-1βInflammatory cytokinesPeriodontitisScaling and root planingTNF-α

Identifiers

PMID41024055
PMCPMC12481980

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.