Evidence map›Paper›PMID 41024013›Full record

ArticleNutrition journal2025

The association of dietary choline intakes with cognitive function among the older people in underdeveloped regions: findings from the NCDFaC study.

Dan Liu, Yingying Niu, Haoyu Yan, Chengping Li, Lianhong Chen, Chenglian Li, Kui Dong, Zhihao Li, Jian Zhang, Zhuoqun Wang and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Dan Liu *Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Yingying Niu *Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
Haoyu YanDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
Chengping LiDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
Lianhong ChenDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
Chenglian LiDepartment of Chronic Disease and Student Health, Shanxi Provincial Centre for Disease Control and Prevention, Taiyuan, China.
Kui DongLinyi Center for Disease Control and Prevention, 1159 Shuangtanan Road, Linyi, 044100, China.
Zhihao LiDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Jian ZhangNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, 100050, China.
Zhuoqun WangNational Center for Chronic and Noncommunicable Disease Control and Prevention, CDC, Beijing, China.
Pengkun SongNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, 100050, China.
Yanfang ZhaoNational Center for Chronic and Noncommunicable Disease Control and Prevention, CDC, Beijing, China.
Yi ZhaiBeijing Tiantan Hospital, National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, China.
Mei ZhangNational Center for Chronic and Noncommunicable Disease Control and Prevention, CDC, Beijing, China.
Shaojie PangInstitute of Grain Quality and Nutrition Research, Academy of National Food and Strategic Reserves Administration, Beijing, People's Republic of China.
Shengquan MiCollege of Biochemical Engineering, Beijing Union University, 18 Zone three, Fatouxili, Chaoyang District, Beijing, China.
Xiaofeng LiangDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
Shuang SongNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, 100050, China.
Zhaoxue YinOffice of Epidemiology, Chinese Center for Disease Control and Prevention, Beijing, China. yinzx@chinacdc.cn.
Wenhua ZhaoNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, 100050, China. zhaowh@chinacdc.cn.

Funding

the Construction of High-level University of Guangdong G624330422the Guangzhou Science and Technology Project 2023A04J0637the National Natural Science Foundation of China 82003443Young Elite Scientists Sponsorship Program by CAST 2019QNRC001
6 · The paper itself

Abstract

objectivesWe aimed to investigate the associations between dietary choline, its subtypes, and cognitive function in older adults from underdeveloped regions of China, using data from the Nutrition and Chronic Disease Family Cohort (NCDFaC) study.

methodsThis cross-sectional study included 1 522 older adults aged 60 and over. Dietary choline intakes were assessed using a food frequency questionnaire, and cognitive function was evaluated with the Mini-Mental State Examination (MMSE). The associations between choline intake and mild cognitive impairment (MCI) were analyzed using logistic regression models, restricted cubic splines and propensity score matching (PSM).

resultAmong the 1 522 participants, 292 (19.2%) were diagnosed with MCI. Compared to those in the lowest quartile of total choline intake, participants in the 2nd quartile (169.0 mg/[1000 kcal*d]) had lower odds of MCI, with an OR (95% CI) of 0.63 (0.42, 0.94). Similarly, participants in the 2nd (116.0 mg/[1000 kcal*d]) and 3rd (148.0 mg/[1000 kcal*d]) quartiles of phosphatidylcholine intake had reduced odds of MCI, with ORs (95% CI) of 0.59 (0.39, 0.88) and 0.60 (0.40, 0.91), respectively. For free choline intake, the highest quartile (74.2 mg/[1000 kcal*d]) was associated with an OR (95% CI) of 0.55 (0.35, 0.86). After PSM, higher intakes of total choline and phosphatidylcholine remained associated with lower odds of MCI.

conclusionModerate to high dietary intakes of total choline, phosphatidylcholine, and free choline may be associated with lower odds of MCI among older adults in underdeveloped regions.

Indexed as

CholineCognitionCognitive DysfunctionDietAgedAged, 80 and overChinaCohort StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedCholineCognitive functionDietary cholineOlder peopleUnderdeveloped regions

Identifiers

PMID41024013
PMCPMC12482226

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.