Cross-sectional analyses between the dietary index for gut microbiota and Parkinson's disease in the middle-aged and elderly population.

Yiming Zhan, Yuhang Liu, Huxingzi Liu, Siyao Gao, Jialing Tang

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Article in Nutrition journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 citing paper in PubMed.

The association between domain-specific physical activity in adults and Parkinson's disease and all-cause mortality: a NHANES study from 2007 to 2018.Biology of sport · 2026
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5 authors.

Yiming ZhanDepartment of Physical Education, Central South University, No.932 South Lushan Road, Yuelu District, Changsha, 410083, P. R. China.

Yuhang LiuSchool of Physical Education and Sports, Central China Normal University, Wuhan, 430079, P. R. China.

Huxingzi LiuDepartment of Physical Education, Central South University, No.932 South Lushan Road, Yuelu District, Changsha, 410083, P. R. China.

Siyao GaoDepartment of Physical Education, Central South University, No.932 South Lushan Road, Yuelu District, Changsha, 410083, P. R. China.

Jialing TangDepartment of Physical Education, Central South University, No.932 South Lushan Road, Yuelu District, Changsha, 410083, P. R. China. tangjialing@csu.edu.cn.

Funding

M.Ed. Tang is supported by grant 22YJC890029, the MOE (Ministry of Education in China) Project of Humanities and Social Sciences. 22YJC890029

6 · The paper itself

Abstract

backgroundThe evidence linking dietary indices to Parkinson's disease (PD) risk remains limited. This study investigated the association between the Dietary Index for Gut Microbiota (DI-GM) and PD risk in middle-aged and elderly populations.

methodsCross-sectional data were obtained from the 2007-2020 cycles of the National Health and Nutrition Examination Survey (NHANES), including 17,373 participants aged 40 years or older. PD was defined by antiparkinsonian medication use. DI-GM scores were calculated based on 14 dietary components. Multiple logistic regression and a restricted cubic spline model (RCS) were used to test the relationship between DI-GM and PD. Subgroup and sensitivity analyses were conducted to evaluate the robustness of the results.

resultsAmong 17,373 participants, those with PD (n = 232) had lower DI-GM scores compared to non-PD individuals. Higher DI-GM scores (≥ 6) were associated with a 49% reduction in PD prevalence. RCS analysis showed a non-linear relationship between DI-GM and PD (P < 0.05). Subgroup and sensitivity analyses confirmed stable associations across demographic groups and after adjusting for comorbidities.

conclusionsA gut microbiota-friendly diet, as measured by DI-GM, is associated with reduced PD risk, especially in the higher DI-GM score. This finding may inform future dietary guidelines for the prevention of PD.

Indexed as

DietGastrointestinal MicrobiomeParkinson DiseaseAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutrition SurveysCross-sectional studyDietary index for gut microbiotaDI-GMNeurodegenerative diseaseParkinson's disease

Identifiers

PMID41024009

DOI10.1186/s12937-025-01206-5

PMCPMC12481752

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