ArticleLipids in health and disease2025
The C-reactive protein-triglyceride-glucose index (CTI) as a predictor of mortality and hospital stay in critically ill patients: a retrospective cohort study.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- The Correlation Analysis of C-Reactive Protein-Triglyceride-Glucose Index with the Severity of Hyperlipidemic Acute Pancreatitis.Digestive diseases and sciences · 2026Article
- C-reactive protein-triglyceride-glucose index and risk of incident depressive symptoms in older adults: an eight-year follow-up study from ELSA.Annals of general psychiatry · 2026Article
- C-reactive protein-triglyceride glucose index and its dynamic trajectories on all-cause mortality in critically ill children: a longitudinal, retrospective cohort study.Pediatric research · 2026Article
- The Association of C-Reactive Protein-Triglyceride Glucose Index with Major Adverse Cardiovascular Events in Patients with Acute Myocardial Infarction.Journal of inflammation research · 2026Article
- C-reactive protein-triglyceride glucose index and controlling nutritional status score for predicting severe sepsis or septic shock in diabetic patients withFrontiers in endocrinology · 2026Article
- Association Between C-Reactive Protein-Triglyceride Glucose Index and Adverse Cardiovascular Outcomes in Acute Coronary Syndrome Patients With Prior Coronary Artery Bypass Grafting.Mediators of inflammation · 2026Article
- Prognostic Value of Composite Biomarkers Integrating Insulin Resistance and Coronary Inflammation for Major Adverse Cardiovascular Events in Post-PCI Patients with Coronary Artery Disease Across Glycemic Status: A Prospective Cohort Study.Journal of inflammation research · 2026Article
- C-reactive protein-triglyceride-glucose index predicts acute pancreatitis severity: a retrospective cross-sectional study.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundPopulation aging has increased the demand for intensive care, with critically ill patients facing high mortality and prolonged hospital stays. New biomarkers are needed to predict outcomes early. The C-reactive protein-triglyceride-glucose index (CTI) integrates insulin resistance and inflammation, but its Link to outcomes in critically ill patients is unknown. This study aims to investigate the association between CTI and 30-day and 365-day all-cause mortality and length of hospital stay in critically ill patients.
methodsThis retrospective study utilized data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database, including 2,428 ICU patients admitted from 2008 to 2022. The primary outcomes were 30-day and 365-day all-cause mortality, while secondary outcomes included length of hospital stay and ICU stay. CTI was calculated based on biochemical data (CRP, triglycerides, and glucose). Kaplan-Meier survival analysis, Cox regression models, and mediation analysis were employed to assess the relationship between CTI and clinical outcomes.
resultsHigher CTI levels were associated with increased all-cause mortality at both 30 days (HR: 1.81, 95% CI: 1.31-2.52, P < 0.001 for the highest quartile) and 365 days (HR: 1.80, 95% CI: 1.43-2.28, P < 0.001 for the highest quartile). CTI exhibited a Linear relationship with mortality, with each unit increase in CTI corresponding to a 25% increase in 30-day mortality and a 26% increase in 365-day mortality. Nutritional risk, assessed by the Geriatric Nutritional Risk Index (GNRI) levels, significantly mediated the association between CTI and mortality, with a stronger effect observed in long-term outcomes. Furthermore, CTI outperformed the triglyceride-glucose (TyG) index and C-reactive protein (CRP) in predicting mortality, and the results remained consistent after adjusting for baseline severity scores. Additionally, higher CTI levels were associated with longer hospital and ICU stays (β = 0.44 days and β = 0.22 days, respectively, P < 0.001).
conclusionsCTI is a robust predictor of mortality and hospital stay duration in critically ill patients, integrating the effects of insulin resistance and inflammation. Nutritional risk plays a significant mediating role in the association between CTI and mortality, particularly in long-term outcomes. CTI may serve as a valuable tool for early risk stratification and clinical decision-making in the ICU setting.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.