ArticleEnvironmental health : a global access science source2025
Short-term exposure to air pollution and risk of ischemic stroke requiring intravenous thrombolysis: a population-level analysis in Poland from the EP-PARTICLES study.
Article in Environmental health : a global access science source, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05198492 (Short- and Long-term Health Effects of Air Pollution in Poland), which is not on this map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Short- and Long-term Health Effects of Air Pollution in Poland
Who cites it
5 citing papers in PubMed.
- Regional Disparities in Stroke Hospitalization and Mortality Associated with Long-Term Fine Particulate Matter Exposure: A Nationwide Ecological Study in Spain.Medical sciences (Basel, Switzerland) · 2026Article
- Machine-learning-based cardiovascular mortality prediction using a cumulative PMScientific reports · 2026Observational
- Spatial analysis of physical activity and ambient air pollution in Kuwait: a cross-sectional study.Scientific reports · 2026Article
- Spatiotemporal analysis of hospitalizations, mortality and access to intravenous thrombolysis for ischemic stroke in Southern Brazil.BMC public health · 2026Article
- Air, Noise, and Light Pollution and Thromboembolic Cardiovascular Complications: A TH Scientific Statement.Thrombosis and haemostasis · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundAir pollution is an important non-classical cardiovascular risk factor. Ischemic stroke (IS) is an increasing healthcare challenge, with the ageing population and associated presence of atrial fibrillation worldwide. In patients with IS, intravenous thrombolysis (IVT) is an effective treatment method within 4.5 hours from symptoms onset. Our aim was to assess the association between exposure to air pollution and IVT-treated IS, allowing for high temporal precision in exposure assessment.
methodsWe conducted a retrospective population-based cohort study including 5.4 million inhabitants in Eastern Poland in the Years 2011-20. IVT-treated IS patients were enrolled into this study based on ICD-10 and ICD-9 code (I63 with 99.101/99.102/99.103). To ensure high spatial resolution, we used the GEM-AQ model for air quality modeling. Generalized linear mixed model with a Poisson distribution and random intercepts were used to examine municipality-specific associations between short-term exposure to air pollutants and IVT-treated IS.
resultsWe recorded 96,189 IS cases with a dominance of females (52.5%) and patients 65 years old and over (78.8%). 10,486 (10.9%) patients received IVT treatment. In this group there was lower share of women (51.3% vs. 52.7%, p < 0.001), fewer elderly individuals (76% vs. 79.1%, p < 0.001), and lower in-hospital mortality (13.6% vs. 15.5%, p < 0.001). The rate of IVT use increased significantly from 3.2% in 2011 to 18.3% in 2020 (Kendall's τ = 0.956, p < 0.001). Exposure to benzo(a)pyrene was associated with the highest negative effects, causing 10.3% and 13.5% increase in risk of IVT-treated IS on LAG 0 and LAG 0-6 in the overall population, respectively. There was also an association between increased PM2.5 and IVT-treated incidence across all analyzed populations. Exposure to NO
conclusionsExposure to air pollution might serve as a trigger for IVT-treated IS, exerting a comparable effect across different sexes and age groups. The IVT-treated IS group was characterized by improved survival. Public health efforts should focus on reducing air pollution levels and ensuring rapid access to advanced IS treatment in high-risk, highly polluted areas.
trial registrationClinicalTrials.gov (NCT05198492).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.