Evidence map›Paper›PMID 41023939›Full record

ArticleBMC neurology2025

Endovascular therapy compared to best medical treatment in Non-ATTENTION patients: a multicenter registry study.

Yong Liang, Song Ouyang, Miao Li, Chenping Li, Kang Ou, Caiyu Ma, Ziling Wang, Wen Sun

Abstract readMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yong LiangDepartment of Neurology, The affiliated Changsha Hospital of Xiangya School of Medicine, Central South University; The First Hospital of Changsha, Changsha, Hunan, P.R. China.
Song OuyangDepartment of Neurology, The affiliated Changsha Hospital of Xiangya School of Medicine, Central South University; The First Hospital of Changsha, Changsha, Hunan, P.R. China.
Miao LiDepartment of Neurology, The affiliated Changsha Hospital of Xiangya School of Medicine, Central South University; The First Hospital of Changsha, Changsha, Hunan, P.R. China.
Chenping LiDepartment of Neurology, The affiliated Changsha Hospital of Xiangya School of Medicine, Central South University; The First Hospital of Changsha, Changsha, Hunan, P.R. China.
Kang OuDepartment of Neurology, The affiliated Changsha Hospital of Xiangya School of Medicine, Central South University; The First Hospital of Changsha, Changsha, Hunan, P.R. China.
Caiyu MaDepartment of Neurology, The affiliated Changsha Hospital of Xiangya School of Medicine, Central South University; The First Hospital of Changsha, Changsha, Hunan, P.R. China.
Ziling WangDepartment of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210002, China. 564875695@qq.com.
Wen SunDepartment of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, Anhui, 230001, China. sunwen_medneuro@163.com.

Funding

Clinical Medical Research and Transformation Special Project in Anhui Province 202427b10020147Natural Science Foundation of Hunan Province of China 2023JJ30062Research Funds of Centre for Leading Medicine and Advanced Technologies of IHM 2023IHM01054
6 · The paper itself

Abstract

backgroundWe aimed to investigate the efficacy and safety of endovascular therapy (EVT) in adult stroke patients with vertebrobasilar artery occlusion (VBAO) not fulfilling the ATTENTION (Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion) inclusion criteria.

methodsWe retrospectively enrolled VBAO patients from 65 Chinese stroke centers (December 2015–June 2022), excluding those meeting ATTENTION criteria. We compared EVT recipients with those receiving best medical treatment (BMT) alone. The primary efficacy outcome was favorable functional outcome (modified Rankin Scale [mRS] 0–3 at 90 days). Safety outcomes included symptomatic intracranial hemorrhage (sICH) and 90-day mortality.

resultsOf 4124 VBAO patients, 1345 (35.6%) did not meet ATTENTION criteria; 472 (35.1%) received EVT. After adjusting for confounders, EVT patients had higher odds of favorable functional outcome (OR 1.44, 95% CI 1.11–1.87), increased sICH risk (OR 1.94, 95% CI 1.06–3.55), and lower mortality (OR 0.54, 95% CI 0.40–0.75) compared to BMT. However, when the NIHSS score in ATTENTION criteria was lowered to ≥ 6, EVT’s advantage over BMT was not statistically significant (OR 1.32, 95% CI 0.93–1.86).

conclusionIn VBAO patients not meeting ATTENTION criteria, EVT was still associated with better functional outcomes. Extending the NIHSS score to ≥ 6 may be a more suitable criterion, supporting broader EVT eligibility to benefit more patients.

Indexed as

Endovascular ProceduresStrokeVertebrobasilar InsufficiencyAgedFemaleHumansMaleMiddle AgedRegistriesRetrospective StudiesTreatment OutcomeEndovascular treatmentOutcomeVertebrobasilar artery occlusion

Identifiers

PMID41023939
PMCPMC12482786

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.